nhl-1 RING finger protein nhl-1;RING-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhl-1
Official Full Name: RING finger protein nhl-1;RING-type domain-containing protein
Primary source: WormBase:WBGene00003597
Locus tag: CELE_F54G8.4
See related: AllianceGenome:WB:WBGene00003597
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Is expressed in body wall musculature; non-striated muscle; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhl-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 13

Sequence:: Chromosome: III; NC_003281.10 (9147395..9153909, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Optogenetic induction of mechanical muscle stress identifies myosin regulatory ubiquitin ligase NHL-1 in C. elegans.
Title: Optogenetic induction of mechanical muscle stress identifies myosin regulatory ubiquitin ligase NHL-1 in C. elegans.
NHL-1 acts in chemosensory neurons to promote stress resistance in distal tissues by DAF-16 activation but is dispensable for the activation of HSF-1.
Title: Differential regulation of the heat shock factor 1 and DAF-16 by neuronal nhl-1 in the nematode C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54G8.4 (e-PCR)
- UniSTS:307699

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RING finger protein nhl-1;RING-type domain-containing protein

NP_001309582.1

Confirmed by transcript evidence

NP_499028.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9147395..9153909 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001322726.2 → NP_001309582.1 RING-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MCD3

Conserved Domains (3) summary

PLN02217
Location:388 → 512

PLN02217; probable pectinesterase/pectinesterase inhibitor

cd14954
Location:641 → 924

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

cd16524
Location:41 → 84

RING-HC_NHL-1_like; RING finger, HC subclass, found in Caenorhabditis elegans RING finger protein NHL-1 and similar proteins
NM_066627.7 → NP_499028.1 RING finger protein nhl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499028.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03601, Q23510

Conserved Domains (4) summary

COG3391
Location:721 → 973

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd14954
Location:691 → 974

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00097
Location:43 → 83

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam09421
Location:426 → 545

FRQ; Frequency clock protein