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    FAM174B family with sequence similarity 174 member B [ Homo sapiens (human) ]

    Gene ID: 400451, updated on 27-Nov-2024

    Summary

    Official Symbol
    FAM174Bprovided by HGNC
    Official Full Name
    family with sequence similarity 174 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:34339
    See related
    Ensembl:ENSG00000185442 AllianceGenome:HGNC:34339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Involved in Golgi organization. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 17.8), thyroid (RPKM 16.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FAM174B in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (92617448..92655775, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (90379890..90418117, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (93160678..93199005, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene chromosome 15 putative open reading frame 32 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:93053451-93053972 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:93061329-93061830 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:93064789-93065381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:93105459-93105998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:93105999-93106536 Neighboring gene long intergenic non-protein coding RNA 930 Neighboring gene MPRA-validated peak2428 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:93156777-93157278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10112 Neighboring gene uncharacterized LOC124903559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:93186854-93187634 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:93187635-93188414 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:93190755-93191534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6842 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:93207617-93208116 Neighboring gene Sharpr-MPRA regulatory region 7580 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6845 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 38 Neighboring gene ribosomal protein L31 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.
    EBI GWAS Catalog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207446.3NP_997329.2  membrane protein FAM174B precursor

      See identical proteins and their annotated locations for NP_997329.2

      Status: VALIDATED

      Source sequence(s)
      AC091544, BC060873
      Consensus CDS
      CCDS45355.1
      UniProtKB/Swiss-Prot
      Q3ZCQ3, Q3ZCR9, Q8NBH7
      Related
      ENSP00000329040.5, ENST00000327355.6
      Conserved Domains (1) summary
      pfam06679
      Location:75158
      DUF1180; Protein of unknown function (DUF1180)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      92617448..92655775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      90379890..90418117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)