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    hpo-18 ATP synthase subunit epsilon, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 178830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hpo-18
    Official Full Name
    ATP synthase subunit epsilon, mitochondrial
    Primary source
    WormBase:WBGene00017982
    Locus tag
    CELE_F32D1.2
    See related
    AllianceGenome:WB:WBGene00017982
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Predicted to be part of proton-transporting ATP synthase complex, catalytic core F(1). Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 3. Orthologous to human ATP5F1E (ATP synthase F1 subunit epsilon) and ATP5F1EP2 (ATP synthase F1 subunit epsilon pseudogene 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hpo-18 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (4346089..4346425, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Recep_L_domain domain-containing protein;Receptor L-domain domain-containing protein Neighboring gene Glutaredoxin 3 Neighboring gene AAA domain-containing protein;Fidgetin-like protein 1;Spastin/Vps4 C-terminal domain-containing protein Neighboring gene DNA replication licensing factor MCM7 Neighboring gene TPR_REGION domain-containing protein;dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhancement in the ATP level and antioxidant capacity of Caenorhabditis elegans under continuous exposure to extremely low-frequency electromagnetic field for multiple generations. Wang Y, et al. Int J Radiat Biol, 2020 Dec. PMID 32991227
    2. ASB-1, a germline-specific isoform of mitochondrial ATP synthase b subunit, is required to maintain the rate of germline development in Caenorhabditis elegans. Kawasaki I, et al. Mech Dev, 2007 Mar. PMID 17223323
    3. The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging. Angeli S, et al. Elife, 2021 Sep 1. PMID 34467850, Free PMC Article
    4. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    5. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit epsilon, mitochondrial
    NP_504198.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4346089..4346425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071797.8 → NP_504198.1  ATP synthase subunit epsilon, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16298
      Conserved Domains (1) summary
      pfam04627
      Location:3 → 50
      ATP-synt_Eps; Mitochondrial ATP synthase epsilon chain
    Nucleotide Protein
    Heading Accession and Version

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