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    gdh-1 Glutamate dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 178130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gdh-1
    Official Full Name
    Glutamate dehydrogenase
    Primary source
    WormBase:WBGene00014095
    Locus tag
    CELE_ZK829.4
    See related
    AllianceGenome:WB:WBGene00014095
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutamate dehydrogenase (NAD+) activity. Predicted to be involved in glutamate catabolic process. Predicted to be active in mitochondrion. Is expressed in head; intestine; pharynx; rectal gland cell; and tail. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gdh-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (11953249..11955541)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene putative aromatic-L-amino-acid decarboxylase Neighboring gene Putative T-box protein 36 Neighboring gene ncRNA Neighboring gene Queuine tRNA-ribosyltransferase catalytic subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteome analysis reveals translational inhibition of Caenorhabditis elegans enhances susceptibility to Pseudomonas aeruginosa PAO1 pathogenesis. Balasubramanian V, et al. J Proteomics, 2016 Aug 11. PMID 27109352
    2. Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans. Tang R, et al. J Genet Genomics, 2020 Mar 20. PMID 32305173
    3. C. elegans ribosomal protein S3 protects against H(2)O(2)-induced DNA damage and suppresses spontaneous mutations in yeast. Elsakrmy N, et al. DNA Repair (Amst), 2022 Sep. PMID 35809390
    4. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Li TY, et al. Nat Aging, 2021 Feb. PMID 33718883, Free PMC Article
    5. Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response. Quach TK, et al. PLoS One, 2013. PMID 23533643, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutamate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutamate dehydrogenase
    NP_502267.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11953249..11955541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069866.7 → NP_502267.1  Glutamate dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23621
      Conserved Domains (3) summary
      cd01076
      Location:241 → 526
      NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
      COG0334
      Location:75 → 533
      GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
      pfam02812
      Location:91 → 218
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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