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    ant-1.1 ADP/ATP translocase [ Caenorhabditis elegans ]

    Gene ID: 176773, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ant-1.1
    Official Full Name
    ADP/ATP translocase
    Primary source
    WormBase:WBGene00006439
    Locus tag
    CELE_T27E9.1
    See related
    AllianceGenome:WB:WBGene00006439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP:ADP antiporter activity. Involved in determination of adult lifespan; mitochondrion organization; and positive regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including body wall musculature; hermaphrodite somatic gonadal cell; intestine; pharynx; and vulva. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ant-1.1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (13463163..13464652)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ABC transporter domain-containing protein Neighboring gene Major sperm protein Neighboring gene Cytochrome b-c1 complex subunit 6 Neighboring gene Cyclin-dependent-like kinase 5 Neighboring gene BTB domain-containing protein Neighboring gene Phosphatidylserine synthase Neighboring gene SET domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic characterization of Tv-ant-1, a Caenorhabditis elegans tag-61 homologue from the parasitic nematode Trichostrongylus vitrinus. Hu M, et al. Gene, 2007 Aug 1. PMID 17512141
    2. Elucidating ANTs in worms using genomic and bioinformatic tools--biotechnological prospects? Hu M, et al. Biotechnol Adv, 2010 Jan-Feb. PMID 19770033
    3. Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans. Farina F, et al. Dev Dyn, 2008 Jun. PMID 18498090
    4. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Shen Q, et al. Mol Cell Biol, 2009 Jul. PMID 19414600, Free PMC Article
    5. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Zhou B, et al. Cell, 2019 Apr 4. PMID 30929899, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP:ADP antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial ADP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial ATP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP/ATP translocase
    NP_001022799.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13463163..13464652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027628.8 → NP_001022799.1  ADP/ATP translocase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45865, Q17407
      Conserved Domains (2) summary
      PTZ00169
      Location:10 → 300
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:8 → 107
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version

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