klp-7 Kinesin-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: klp-7
Official Full Name: Kinesin-like protein
Primary source: WormBase:WBGene00002219
Locus tag: CELE_K11D9.1
See related: AllianceGenome:WB:WBGene00002219
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables kinetochore binding activity. Involved in several processes, including egg-laying behavior; maintenance of centrosome location; and microtubule cytoskeleton organization. Located in centrosome; kinetochore; and meiotic spindle pole. Is expressed in body wall muscle quadrant; distal tip cell; neurons; seam cell; and tail. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A); KIF2B (kinesin family member 2B); and KIF2C (kinesin family member 2C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See klp-7 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (10805925..10811001)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt signaling establishes the microtubule polarity in neurons through regulation of Kinesin-13.
Title: Wnt signaling establishes the microtubule polarity in neurons through regulation of Kinesin-13.
the kinesin-13 KLP-7 promotes destabilization of the whole cellular microtubule network.
Title: Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes.
KLP-7/MCAK regulates k-MT attachment and spindle tension to promote the coalescence of early spindle pole foci that produces a bipolar structure during the acentrosomal process of oocyte meiotic spindle assembly.
Title: KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly.
The number of growing microtubules increases at the injury site, concomitant with local downregulation of KLP-7.
Title: Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K11D9.1 (e-PCR)
- UniSTS:312695

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables kinetochore binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in astral microtubule organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytoplasmic microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of centrosome location	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to centrosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle, embryonic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cytokinetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Kinesin-like protein

NP_001022677.1

Confirmed by transcript evidence

NP_001022678.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10805925..10811001

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027506.4 → NP_001022677.1 Kinesin-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022677.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MYB5, Q9XU12

Conserved Domains (2) summary

cd01367
Location:320 → 648

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:326 → 649

Kinesin; Kinesin motor domain
NM_001027507.4 → NP_001022678.1 Kinesin-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022678.1

Status: REVIEWED

UniProtKB/TrEMBL

G5ED75, Q8MYB5

Conserved Domains (2) summary

cd01367
Location:262 → 590

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:268 → 591

Kinesin; Kinesin motor domain