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    dac-1 Dachshund homolog dac-1 [ Caenorhabditis elegans ]

    Gene ID: 175238, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dac-1
    Official Full Name
    Dachshund homolog dac-1
    Primary source
    WormBase:WBGene00000895
    Locus tag
    CELE_B0412.1
    See related
    AllianceGenome:WB:WBGene00000895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in thermotaxis. Located in nucleus. Is expressed in amphid neurons; cuticular ala; head neurons; seam cell; and tail. Orthologous to several human genes including DACH1 (dachshund family transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dac-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (816145..821730)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Foie-gras_1 domain-containing protein;TRAPP II complex TRAPPC10 C-terminal domain-containing protein;Trafficking protein particle complex subunit 11 domain-containing protein Neighboring gene Dauer larva development regulatory growth factor daf-7 Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Epoxide hydrolase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types. Colosimo ME, et al. Curr Biol, 2004 Dec 29. PMID 15620651
    2. Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity. Harris N, et al. Curr Biol, 2023 Apr 24. PMID 36977417, Free PMC Article
    3. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
    4. A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm. Amin NM, et al. Dev Biol, 2009 Jul 15. PMID 19427847, Free PMC Article
    5. The regulatory content of intergenic DNA shapes genome architecture. Nelson CE, et al. Genome Biol, 2004. PMID 15059258, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dac-1 is expressed in a subset of sensory neurons including the AFD thermosensory neurons and is regulated by the TTX-1 OTX homeodomain protein.
      Title: Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dachshund homolog dac-1
    NP_001021129.1
    • Confirmed by transcript evidence
    NP_001021130.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      816145..821730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025958.4 → NP_001021129.1  Dachshund homolog dac-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KY91, Q86GT3
      Conserved Domains (1) summary
      cd21081
      Location:84 → 176
      DHD_Dac; Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins

    2. NM_001025959.5 → NP_001021130.1  Dachshund homolog dac-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021130.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86GT3
      Conserved Domains (1) summary
      pfam02437
      Location:1 → 73
      Ski_Sno; SKI/SNO/DAC family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H2KY91.1

    Gene LinkOut

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