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    thk-1 Thymidine kinase [ Caenorhabditis elegans ]

    Gene ID: 177913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    thk-1
    Official Full Name
    Thymidine kinase
    Primary source
    WormBase:WBGene00006568
    Locus tag
    CELE_Y43C5A.5
    See related
    AllianceGenome:WB:WBGene00006568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables thymidine kinase activity. Predicted to be involved in thymidine metabolic process. Orthologous to human TK1 (thymidine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See thk-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (10279459..10281582, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene CaeNaCin (Caenorhabditis bacteriocin) Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene DNA repair protein RAD51 homolog Neighboring gene SWIM-type domain-containing protein Neighboring gene PH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of wild-type and mutant TK1 type kinases from Caenorhabditis elegans. Skovgaard T, et al. Nucleosides Nucleotides Nucleic Acids, 2006. PMID 17065083
    2. Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1. Skovgaard T, et al. FEBS J, 2012 May. PMID 22385435
    3. Thymidine kinase 1 regulatory fine-tuning through tetramer formation. Mutahir Z, et al. FEBS J, 2013 Mar. PMID 23351158
    4. Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans. Kim S, et al. FEBS J, 2009 Sep. PMID 19645718
    5. Regulation of the one carbon folate cycle as a shared metabolic signature of longevity. Annibal A, et al. Nat Commun, 2021 Jun 9. PMID 34108489, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1
      Title: Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1.
    2. CeTK1 exclusively exists as a dimer with a molecular mass of approximately 60 kDa, even if incubated with ATP
      Title: Purification and characterization of wild-type and mutant TK1 type kinases from Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deoxyribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thymidine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Thymidine kinase
    NP_001255478.1
    • Confirmed by transcript evidence
    NP_001369806.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10279459..10281582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268549.3 → NP_001255478.1  Thymidine kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255478.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3Y5P8
      Conserved Domains (1) summary
      cl23762
      Location:24 → 222
      TK; Thymidine kinase

    2. NM_001383184.2 → NP_001369806.1  Thymidine kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEZ5
      Conserved Domains (1) summary
      cl23762
      Location:33 → 231
      TK; Thymidine kinase
    Nucleotide Protein
    Heading Accession and Version

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