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    nit-1 CN hydrolase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nit-1
    Official Full Name
    CN hydrolase domain-containing protein
    Primary source
    WormBase:WBGene00014206
    Locus tag
    CELE_ZK1058.6
    See related
    AllianceGenome:WB:WBGene00014206
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydro-lyase activity and nitrilase activity. Is expressed in several structures, including E; Ea; Ep; MS; and MSa. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nit-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (3922207..3923873)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PAT complex subunit CCDC47 Neighboring gene putative galactose-1-phosphate uridylyltransferase Neighboring gene tRNA N(3)-methylcytidine methyltransferase Neighboring gene Uncharacterized protein Neighboring gene mRNA 5'-triphosphatase Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene expression profiling studies on Caenorhabditis elegans dystrophin mutants dys-1(cx-35) and dys-1(cx18). Towers PR, et al. Genomics, 2006 Nov. PMID 16962739
    2. Neuron-specific proteasome activation exerts cell non-autonomous protection against amyloid-beta (Aβ) proteotoxicity in Caenorhabditis elegans. Panagiotidou E, et al. Redox Biol, 2023 Sep. PMID 37473700, Free PMC Article
    3. ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1. Statzer C, et al. Nat Commun, 2022 Feb 18. PMID 35181679, Free PMC Article
    4. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrilase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CN hydrolase domain-containing protein
    NP_497791.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3922207..3923873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065390.2 → NP_497791.1  CN hydrolase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23384
      Conserved Domains (1) summary
      cd07564
      Location:3 → 296
      nitrilases_CHs; Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases)
    Nucleotide Protein
    Heading Accession and Version

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