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    mogs-1 Mannosyl-oligosaccharide glucosidase [ Caenorhabditis elegans ]

    Gene ID: 177998, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mogs-1
    Official Full Name
    Mannosyl-oligosaccharide glucosidase
    Primary source
    WormBase:WBGene00008775
    Locus tag
    CELE_F13H10.4
    See related
    AllianceGenome:WB:WBGene00008775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mogs-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (11016224..11021670, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cysteine-rich transmembrane CYSTM domain-containing protein Neighboring gene NAD(+) diphosphatase;NAD-capped RNA hydrolase ndx-9 Neighboring gene Amino acid transporter transmembrane domain-containing protein;Sodium-coupled neutral amino acid transporter 9 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ABC transporter permease;Small subunit of serine palmitoyltransferase Neighboring gene 10-formyltetrahydrofolate dehydrogenase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficiency of α-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans. Katoh T, et al. Glycobiology, 2013 Oct. PMID 23836288, Free PMC Article
    2. Gut commensal E. coli outer membrane proteins activate the host food digestive system through neural-immune communication. Geng S, et al. Cell Host Microbe, 2022 Oct 12. PMID 36057258
    3. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mannosyl-oligosaccharide glucosidase
    NP_001076681.1
    • Confirmed by transcript evidence
    NP_001076682.1
    • Confirmed by transcript evidence
    NP_001122771.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11016224..11021670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083213.5 → NP_001076682.1  Mannosyl-oligosaccharide glucosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076682.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19426
      Conserved Domains (2) summary
      pfam03200
      Location:303 → 785
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:82 → 246
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

    2. NM_001083212.4 → NP_001076681.1  Mannosyl-oligosaccharide glucosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5JYS7, Q0G829, Q0G830, Q19426
      Conserved Domains (2) summary
      pfam03200
      Location:310 → 792
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:89 → 253
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

    3. NM_001129299.5 → NP_001122771.1  Mannosyl-oligosaccharide glucosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122771.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19426
      Conserved Domains (2) summary
      pfam03200
      Location:306 → 788
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:82 → 246
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19426.2

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