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    mth-2 GPS domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mth-2
    Official Full Name
    GPS domain-containing protein
    Primary source
    WormBase:WBGene00017947
    Locus tag
    CELE_F31D5.4
    See related
    AllianceGenome:WB:WBGene00017947
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in X-linked congenital bilateral absence of vas deferens and vibratory urticaria. Orthologous to human ADGRE2 (adhesion G protein-coupled receptor E2); ADGRG2 (adhesion G protein-coupled receptor G2); and ADGRG7 (adhesion G protein-coupled receptor G7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mth-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    15
    Sequence:
    Chromosome: II; NC_003280.10 (4188976..4194314, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box associated domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Copine family protein 1 Neighboring gene GPS domain-containing protein Neighboring gene NfeD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GPS domain-containing protein
    NP_001364698.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4188976..4194314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377778.1 → NP_001364698.1  GPS domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19930, Q6W3C4
      Conserved Domains (3) summary
      smart00303
      Location:607 → 656
      GPS; G-protein-coupled receptor proteolytic site domain
      cd14964
      Location:664 → 690
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:662 → 933
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version

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