jun-1 BZIP domain-containing protein;Transcription factor jun-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: jun-1
Official Full Name: BZIP domain-containing protein;Transcription factor jun-1
Primary source: WormBase:WBGene00012005
Locus tag: CELE_T24H10.7
See related: AllianceGenome:WB:WBGene00012005
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Is expressed in several structures, including excretory cell; hermaphrodite gonad; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma; melanoma; and pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See jun-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (9113157..9132231)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that nhr-6 and jun-1 function together to regulate development of the spermatheca and are necessary for generating an organ with the normal number of cells.
Title: C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.
Results provide evidence that C. elegans fos-1 and jun-1 control ovulation, a tightly regulated rhythmic program in animals.
Title: Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T24H10.2 (e-PCR)
- UniSTS:317165

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to steroid hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BZIP domain-containing protein;Transcription factor jun-1

NP_001022366.1

Confirmed by transcript evidence

NP_001022367.1

Confirmed by transcript evidence

NP_001022368.1

Partially confirmed by transcript evidence

NP_001129827.1

Partially confirmed by transcript evidence

NP_001343785.1

Confirmed by transcript evidence

NP_001343786.1

Confirmed by transcript evidence

NP_001343787.1

Confirmed by transcript evidence

NP_001343788.1

Confirmed by transcript evidence

NP_001370235.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9113157..9132231

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027195.4 → NP_001022366.1 Transcription factor jun-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022366.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B2CXX6, B2CXX7, B2CXX9, B5U8L4, G5EC66, G5ECU7, G5EF64, Q5FC74

Conserved Domains (2) summary

cd14696
Location:246 → 306

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

pfam14796
Location:82 → 140

AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
NM_001027196.5 → NP_001022367.1 Transcription factor jun-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022367.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECU7

Conserved Domains (2) summary

cd14696
Location:226 → 286

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

pfam14796
Location:62 → 120

AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
NM_001356878.3 → NP_001343785.1 BZIP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3K0

Conserved Domains (2) summary

PTZ00266
Location:136 → 243

PTZ00266; NIMA-related protein kinase; Provisional

cd14696
Location:194 → 254

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
NM_001356879.3 → NP_001343787.1 BZIP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2T0

Conserved Domains (2) summary

PTZ00266
Location:122 → 229

PTZ00266; NIMA-related protein kinase; Provisional

cd14696
Location:180 → 240

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
NM_001356880.3 → NP_001343788.1 BZIP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2Y8

Conserved Domains (2) summary

PTZ00266
Location:85 → 192

PTZ00266; NIMA-related protein kinase; Provisional

cd14696
Location:143 → 203

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
NM_001356881.3 → NP_001343786.1 BZIP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3E7

Conserved Domains (1) summary

cd14696
Location:102 → 162

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
NM_001383910.2 → NP_001370235.1 Transcription factor jun-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14696
Location:82 → 142

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
NM_001136355.4 → NP_001129827.1 Transcription factor jun-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129827.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECU7

Conserved Domains (1) summary

cd14696
Location:91 → 151

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
NM_001027197.5 → NP_001022368.1 Transcription factor jun-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022368.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECU7

Conserved Domains (1) summary

cd14696
Location:28 → 88

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain