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    acsd-1 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [ Caenorhabditis elegans ]

    Gene ID: 175280, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acsd-1
    Official Full Name
    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
    Primary source
    WormBase:WBGene00022104
    Locus tag
    CELE_Y71D11A.3
    See related
    AllianceGenome:WB:WBGene00022104
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aminocarboxymuconate-semialdehyde decarboxylase activity. Predicted to be involved in negative regulation of quinolinate biosynthetic process and secondary metabolic process. Predicted to be active in cytosol. Orthologous to human ACMSD (aminocarboxymuconate semialdehyde decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acsd-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (1116466..1142927)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Excretory canal abnormal protein 6 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene ncRNA Neighboring gene putative ligand-gated ion channel 46 Neighboring gene ncRNA Neighboring gene Tudor domain-containing protein Neighboring gene Cadherin domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo NAD(+) synthesis enhances mitochondrial function and improves health. Katsyuba E, et al. Nature, 2018 Nov. PMID 30356218, Free PMC Article
    2. High-throughput behavioral analysis in C. elegans. Swierczek NA, et al. Nat Methods, 2011 Jun 5. PMID 21642964, Free PMC Article
    3. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminocarboxymuconate-semialdehyde decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminocarboxymuconate-semialdehyde decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of quinolinate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of quinolinate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in secondary metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
    NP_001022935.1
    • Confirmed by transcript evidence
    NP_001360068.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1116466..1142927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373845.2 → NP_001360068.1  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y54
      Conserved Domains (1) summary
      pfam04909
      Location:57 → 342
      Amidohydro_2; Amidohydrolase

    2. NM_001027764.3 → NP_001022935.1  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022935.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T8B9
      Conserved Domains (1) summary
      pfam04909
      Location:57 → 391
      Amidohydro_2; Amidohydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8B9.1

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