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    hgap-1 Rap-GAP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hgap-1
    Official Full Name
    Rap-GAP domain-containing protein
    Primary source
    WormBase:WBGene00021209
    Locus tag
    CELE_Y18H1A.3
    See related
    AllianceGenome:WB:WBGene00021209
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Involved in determination of adult lifespan. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human RALGAPA1 (Ral GTPase activating protein catalytic subunit alpha 1) and RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hgap-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (700278..715875, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Histidine phosphatase family protein Neighboring gene CBF1-interacting co-repressor CIR N-terminal domain-containing protein;Cir_N domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ATP-dependent DNA helicase;ATP-dependent DNA helicase PIF1 Neighboring gene RGS domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RAL-1 signaling regulates lipid composition in C. elegans. Wu Y, et al. MicroPubl Biol, 2024. PMID 38454952, Free PMC Article
    2. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Martin TD, et al. Mol Cell, 2014 Jan 23. PMID 24389102, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rap-GAP domain-containing protein
    NP_001293169.1
    • Confirmed by transcript evidence
    NP_001293170.1
    • Confirmed by transcript evidence
    NP_001293171.1
    • Confirmed by transcript evidence
    NP_001367998.1
    • Confirmed by transcript evidence
    NP_001368371.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      700278..715875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380470.3 → NP_001367998.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL92
      Conserved Domains (1) summary
      pfam02145
      Location:993 → 1148
      Rap_GAP; Rap/ran-GAP

    2. NM_001380463.2 → NP_001368371.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLC2
      Conserved Domains (1) summary
      pfam02145
      Location:1111 → 1266
      Rap_GAP; Rap/ran-GAP

    3. NM_001306242.3 → NP_001293171.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293171.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLD4
      Conserved Domains (1) summary
      pfam02145
      Location:772 → 927
      Rap_GAP; Rap/ran-GAP

    4. NM_001306241.3 → NP_001293170.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293170.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJZ0
      Conserved Domains (1) summary
      pfam02145
      Location:553 → 708
      Rap_GAP; Rap/ran-GAP

    5. NM_001306240.3 → NP_001293169.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CIT8
      Conserved Domains (1) summary
      pfam02145
      Location:414 → 569
      Rap_GAP; Rap/ran-GAP
    Nucleotide Protein
    Heading Accession and Version

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