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    spe-5 V-type proton ATPase subunit B 2 [ Caenorhabditis elegans ]

    Gene ID: 172137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spe-5
    Official Full Name
    V-type proton ATPase subunit B 2
    Primary source
    WormBase:WBGene00004959
    Locus tag
    CELE_Y110A7A.12
    See related
    AllianceGenome:WB:WBGene00004959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in intracellular pH reduction; positive regulation of programmed cell death; and spermatocyte division. Located in cytoplasm. Is expressed in sperm and spermatocyte. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy and renal tubular acidosis. Orthologous to human ATP6V1B1 (ATPase H+ transporting V1 subunit B1) and ATP6V1B2 (ATPase H+ transporting V1 subunit B2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spe-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (5101665..5103476, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Inactive tyrosine-protein kinase kin-32 Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Intraflagellar transport protein 20 homolog Neighboring gene ncRNA Neighboring gene Cysteine and histidine-rich domain-containing protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans spe-5 gene is required for morphogenesis of a sperm-specific organelle and is associated with an inherent cold-sensitive phenotype. Machaca K, et al. Genetics, 1997 Jun. PMID 9178007, Free PMC Article
    2. Developmental genetics of secretory vesicle acidification during Caenorhabditis elegans spermatogenesis. Gleason EJ, et al. Genetics, 2012 Jun. PMID 22446317, Free PMC Article
    3. The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Syntichaki P, et al. Curr Biol, 2005 Jul 12. PMID 16005300
    4. Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode Caenorhabditis elegans. L'Hernault SW, et al. Genetics, 1988 Oct. PMID 3197956, Free PMC Article
    5. Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms? Lee SK, et al. Biochim Biophys Acta, 2010 Oct. PMID 20637717

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular pH reduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatocyte division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit B 2
    NP_491518.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5101665..5103476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059117.4 → NP_491518.1  V-type proton ATPase subunit B 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N5A0
      Conserved Domains (1) summary
      TIGR01040
      Location:40 → 501
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N5A0.1

    Gene LinkOut

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