ttx-7 Inositol monophosphatase ttx-7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ttx-7
Official Full Name: Inositol monophosphatase ttx-7
Primary source: WormBase:WBGene00008765
Locus tag: CELE_F13G3.5
See related: AllianceGenome:WB:WBGene00008765
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in chemotaxis; protein localization to synapse; and thermotaxis. Located in cytoplasm. Is expressed in several structures, including coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; intellectual disability; and schizophrenia. Orthologous to human IMPA1 (inositol monophosphatase 1) and IMPA2 (inositol monophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ttx-7 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (7300999..7302975, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the PIP(2) signaling regulated by IMPase plays a novel and fundamental role in the synaptic polarity.
Title: Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F13G3.6 (e-PCR)
- UniSTS:321364

F13G3.5 (e-PCR)
- UniSTS:315265

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol monophosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 1-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables inositol monophosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 4-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lithium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Inositol monophosphatase ttx-7

NP_001122453.2

Confirmed by transcript evidence

NP_001122454.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7300999..7302975 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001128981.7 → NP_001122453.2 Inositol monophosphatase ttx-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122453.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A5A8G3, A5A8G4, A5JYT5, Q19420

Conserved Domains (1) summary

cd01639
Location:13 → 263

IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...
NM_001128982.7 → NP_001122454.2 Inositol monophosphatase ttx-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122454.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19420

Conserved Domains (1) summary

cd01639
Location:13 → 260

IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...