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    TRIM67 tripartite motif containing 67 [ Homo sapiens (human) ]

    Gene ID: 440730, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TRIM67provided by HGNC
    Official Full Name
    tripartite motif containing 67provided by HGNC
    Primary source
    HGNC:HGNC:31859
    See related
    Ensembl:ENSG00000119283 MIM:610584; AllianceGenome:HGNC:31859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNL
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of protein localization. Predicted to act upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 4.1) and adrenal (RPKM 0.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM67 in Genome Data Viewer
    Location:
    1q42.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (231162058..231221565)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (230544922..230604828)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231297804..231357311)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 4 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:231174678-231175359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1948 Neighboring gene family with sequence similarity 89 member A Neighboring gene CRISPRi-validated cis-regulatory element chr1.12443 Neighboring gene CRISPRi-validated cis-regulatory element chr1.12444 Neighboring gene CRISPRi-validated cis-regulatory element chr1.12445 Neighboring gene Sharpr-MPRA regulatory region 4964 Neighboring gene CRISPRi-validated cis-regulatory element chr1.12446 Neighboring gene peptidylprolyl isomerase A like 4C pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:231298070-231298704 Neighboring gene NANOG hESC enhancer GRCh37_chr1:231319561-231320089 Neighboring gene TRIM67 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231350707-231351208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231352923-231353422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231356573-231357073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2725 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:231376971-231377860 Neighboring gene 40S small subunit processome assembly factor 1 Neighboring gene glyceronephosphate O-acyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TRIM67 interacts with ENAH to regulate the apoptosis and autophagy of lung cancer cells. Liu R, et al. Gen Physiol Biophys, 2024 Mar. PMID 38477606
    2. Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease. Huang C, et al. Int J Mol Sci, 2022 Jul 5. PMID 35806477, Free PMC Article
    3. TRIM67 Activates p53 to Suppress Colorectal Cancer Initiation and Progression. Wang S, et al. Cancer Res, 2019 Aug 15. PMID 31239268
    4. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. Short KM, et al. J Biol Chem, 2006 Mar 31. PMID 16434393
    5. Mammalian TRIM67 Functions in Brain Development and Behavior. Boyer NP, et al. eNeuro, 2018 May-Jun. PMID 29911180, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ44831

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 67
    Names
    TRIM9-like protein TNL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004342.5 → NP_001004342.3  tripartite motif-containing protein 67 isoform 1

      See identical proteins and their annotated locations for NP_001004342.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL109810, AL137801
      Consensus CDS
      CCDS44333.1
      UniProtKB/Swiss-Prot
      Q5TER7, Q5TER8, Q6ZTA4, Q7Z4K7
      Related
      ENSP00000355613.5, ENST00000366653.6
      Conserved Domains (5) summary
      smart00502
      Location:347 → 473
      BBC; B-Box C-terminal domain
      cd00063
      Location:528 → 604
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00643
      Location:301 → 340
      zf-B_box; B-box zinc finger
      cd12889
      Location:601 → 772
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cl17238
      Location:7 → 45
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_001300889.3 → NP_001287818.1  tripartite motif-containing protein 67 isoform 2

      See identical proteins and their annotated locations for NP_001287818.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame segments in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL109810, AL137801
      Consensus CDS
      CCDS73048.1
      UniProtKB/Swiss-Prot
      Q6ZTA4
      Related
      ENSP00000400163.3, ENST00000449018.7
      Conserved Domains (5) summary
      smart00502
      Location:285 → 411
      BBC; B-Box C-terminal domain
      cd00063
      Location:466 → 542
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00643
      Location:239 → 278
      zf-B_box; B-box zinc finger
      cd12889
      Location:539 → 710
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cl17238
      Location:7 → 30
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_001410937.1 → NP_001397866.1  tripartite motif-containing protein 67 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL109810, AL137801
      Consensus CDS
      CCDS91173.1
      UniProtKB/TrEMBL
      F8W8C1
      Related
      ENSP00000412124.3, ENST00000444294.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      231162058..231221565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      230544922..230604828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZTA4.3 GenPept UniProtKB/Swiss-Prot:Q6ZTA4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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