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    Foxj3 forkhead box J3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313554, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Foxj3provided by RGD
    Official Full Name
    forkhead box J3provided by RGD
    Primary source
    RGD:1311770
    See related
    EnsemblRapid:ENSRNOG00000061851 AllianceGenome:RGD:1311770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in male meiosis I; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Predicted to be located in nucleus. Orthologous to human FOXJ3 (forkhead box J3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 77.4), Heart (RPKM 72.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Foxj3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (138425623..138513760)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (133140344..133228489)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (138587968..138676948)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger, MYND-type containing 12 Neighboring gene ribosomal modification protein rimK-like family member A Neighboring gene ribosomal protein S27a, pseudogene 1 Neighboring gene ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Neighboring gene guanylate cyclase activator 2A Neighboring gene guanylate cyclase activator 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Live-cell monitoring of periodic gene expression in synchronous human cells identifies Forkhead genes involved in cell cycle control. Grant GD, et al. Mol Biol Cell, 2012 Aug. PMID 22740631, Free PMC Article
    2. DNA-binding specificities of human transcription factors. Jolma A, et al. Cell, 2013 Jan 17. PMID 23332764
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein J3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107971.4 → NP_001101441.1  forkhead box protein J3

      See identical proteins and their annotated locations for NP_001101441.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JWM4, A6JZP5
      Conserved Domains (2) summary
      COG5025
      Location:54 → 345
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd20052
      Location:77 → 155
      FH_FOXJ3; Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      138425623..138513760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110006.1 → XP_038965934.1  forkhead box protein J3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWM4, A6JZP5
      Conserved Domains (2) summary
      COG5025
      Location:54 → 345
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd20052
      Location:77 → 155
      FH_FOXJ3; Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins

    2. XM_039110009.1 → XP_038965937.1  forkhead box protein J3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ64
      Conserved Domains (2) summary
      COG5025
      Location:54 → 311
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd20024
      Location:78 → 154
      FH_FOXJ2-like; Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins

    3. XM_039110007.1 → XP_038965935.1  forkhead box protein J3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWM4, A6JZP5
      Related
      ENSRNOP00000096130.2, ENSRNOT00000103629.2
      Conserved Domains (2) summary
      COG5025
      Location:54 → 345
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd20052
      Location:77 → 155
      FH_FOXJ3; Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins

    4. XM_063287744.1 → XP_063143814.1  forkhead box protein J3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ64

    5. XM_039110008.2 → XP_038965936.1  forkhead box protein J3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWM4, A6JZP5
      Related
      ENSRNOP00000069938.3, ENSRNOT00000083754.3
      Conserved Domains (2) summary
      COG5025
      Location:54 → 345
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd20052
      Location:77 → 155
      FH_FOXJ3; Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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