Dnai3 dynein axonemal intermediate chain 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnai3provided by RGD
Official Full Name: dynein axonemal intermediate chain 3provided by RGD
Primary source: RGD:1563105
See related: EnsemblRapid:ENSRNOG00000014893 AllianceGenome:RGD:1563105
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wdr63; RGD1563105
Summary: Predicted to enable Arp2/3 complex binding activity; dynein heavy chain binding activity; and dynein light chain binding activity. Predicted to be involved in several processes, including inner dynein arm assembly; negative regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of osteoblast differentiation. Predicted to be located in cytoplasm. Predicted to be part of inner dynein arm. Orthologous to human DNAI3 (dynein axonemal intermediate chain 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 105.8), Lung (RPKM 63.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (237608202..237666465, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (234947910..235006173, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (251912432..251970699, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	ISO Inferred from Sequence Orthology more info
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of axonemal dynein complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of inner dynein arm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dynein axonemal intermediate chain 3

Names: WD repeat domain 63; WD repeat-containing protein 63; dynein intermediate chain 3, axonemal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.