Setd7 SET domain containing 7, histone lysine methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Setd7provided by RGD
Official Full Name: SET domain containing 7, histone lysine methyltransferaseprovided by RGD
Primary source: RGD:1586346
See related: EnsemblRapid:ENSRNOG00000013045 AllianceGenome:RGD:1586346
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables chromatin binding activity. Involved in positive regulation of DNA-templated transcription and response to ethanol. Predicted to be located in nucleolus. Predicted to be active in chromosome and nucleus. Used to study extrahepatic cholestasis. Biomarker of fetal alcohol spectrum disorder. Orthologous to human SETD7 (SET domain containing 7, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 658.1), Brain (RPKM 231.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (137713545..137756319, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (135562683..135605468, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (140576188..140618405, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SET domain containing 7 promotes oxygen-glucose deprivation/reoxygenation-induced PC12 cell inflammation and oxidative stress by regulating Keap1/Nrf2/ARE and NF-kappaB pathways.
Title: SET domain containing 7 promotes oxygen-glucose deprivation/reoxygenation-induced PC12 cell inflammation and oxidative stress by regulating Keap1/Nrf2/ARE and NF-κB pathways.
SetD7 (Set7/9) is a novel target of PPARgamma that promotes the adaptive pancreatic beta-cell glycemic response.
Title: SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response.
Role of SET7/9 in the progression of ischemic renal injury in diabetic and non-diabetic rats.
Title: Role of SET7/9 in the progression of ischemic renal injury in diabetic and non-diabetic rats.
SETD7 mediates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury.
Title: SETD7 mediates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury.
Setd7 plays an positive role in osteogenic differentiation
Title: Setd7 and its contribution to Boron-induced bone regeneration in Boron-mesoporous bioactive glass scaffolds.
SETD7 gene silencing attenuates hypoxia/reoxygenation-induced injury of cardiomyocytes via the down-regulation of Keap1 and promotion of the Nrf2-mediated anti-oxidation signaling pathway.
Title: Inhibition of SETD7 protects cardiomyocytes against hypoxia/reoxygenation-induced injury through regulating Keap1/Nrf2 signaling.
Overexpression of rno-miR-1298 markedly reduced the expression of SETD 7 at protein level. Knockdown of SETD 7 also suppressed proliferation and promoted apoptosis in C6 cells. It was indicated that rno-miR-1298 affected cell proliferation and apoptosis of rat tumor cells by targeting SETD 7.
Title: MiR-1298 affects cell proliferation and apoptosis in C6 cells by targeting SET domain containing 7.
SET7/9 Recruitment to p21 Gene Promoter Was Increased under Diabetic Conditions
Title: Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.

Submit: New GeneRIF Correction

General gene information

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Markers

AU046527 (e-PCR)
- UniSTS:111366

AI011764 (e-PCR)
- UniSTS:250132

BM387085 (e-PCR)
- UniSTS:261252

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K4 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heterochromatin organization	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transferase activity	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine dimethylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-lysine methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine monomethylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein methylation	ISO Inferred from Sequence Orthology more info
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase SETD7

Names: SET domain containing (lysine methyltransferase) 7

NP_001103028.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.