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    Nxnl1 nucleoredoxin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306342, updated on 27-Dec-2024

    Summary

    Symbol
    Nxnl1provided by RGD
    Full Name
    nucleoredoxin-like 1provided by RGD
    Primary source
    RGD:1308296
    See related
    AllianceGenome:RGD:1308296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Txnl6
    Summary
    Predicted to enable receptor ligand activity. Predicted to be involved in photoreceptor cell maintenance. Orthologous to human NXNL1 (nucleoredoxin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 13.2), Adrenal (RPKM 10.4) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nxnl1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18303454..18311510, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18270604..18279797, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19992211..19996815, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase like 1 Neighboring gene multivesicular body subunit 12A Neighboring gene transmembrane protein 221 Neighboring gene solute carrier family 27 member 1 Neighboring gene 6-phosphogluconolactonase Neighboring gene niban apoptosis regulator 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    nucleoredoxin-like protein 1
    Names
    thioredoxin-like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271341.2NP_001258270.1  nucleoredoxin-like protein 1

      See identical proteins and their annotated locations for NP_001258270.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2K4X6
      Conserved Domains (1) summary
      cd03008
      Location:8153
      TryX_like_RdCVF; Tryparedoxin (TryX)-like family, Rod-derived cone viability factor (RdCVF) subfamily; RdCVF is a thioredoxin (TRX)-like protein specifically expressed in photoreceptors. RdCVF was isolated and identified as a factor that supports cone survival in retinal ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18303454..18311510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094485.2XP_038950413.1  nucleoredoxin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4X6
      Conserved Domains (1) summary
      cd03008
      Location:8153
      TryX_like_RdCVF; Tryparedoxin (TryX)-like family, Rod-derived cone viability factor (RdCVF) subfamily; RdCVF is a thioredoxin (TRX)-like protein specifically expressed in photoreceptors. RdCVF was isolated and identified as a factor that supports cone survival in retinal ...

    RNA

    1. XR_001841535.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107302.2: Suppressed sequence

      Description
      NM_001107302.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.