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    Slc7a9 solute carrier family 7 member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc7a9provided by RGD
    Official Full Name
    solute carrier family 7 member 9provided by RGD
    Primary source
    RGD:619905
    See related
    EnsemblRapid:ENSRNOG00000012344 AllianceGenome:RGD:619905
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables amino acid transmembrane transporter activity. Involved in amino acid transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC7A9 (solute carrier family 7 member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 399.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc7a9 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (97246253..97269546)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (88109517..88132653)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91709034..91738492)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene rhophilin, Rho GTPase binding protein 2 Neighboring gene FA core complex associated protein 24 Neighboring gene centrosomal protein 89 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene tudor domain containing 12 Neighboring gene nudix hydrolase 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter. Shigeta Y, et al. Kidney Int, 2006 Apr. PMID 16609684
    2. Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein. Chairoungdua A, et al. J Biol Chem, 1999 Oct 8. PMID 10506124
    3. Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo,+AT) of rBAT. Feliubadaló L, et al. Nat Genet, 1999 Sep. PMID 10471498
    4. Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney. Kwak JO, et al. J Nephrol, 2005 Nov-Dec. PMID 16358225
    5. rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney. Fernández E, et al. Am J Physiol Renal Physiol, 2002 Sep. PMID 12167606

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC114282

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-cystine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-cystine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-cystine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables broad specificity neutral L-amino acid:basic L-amino acid antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables broad specificity neutral L-amino acid:basic L-amino acid antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide antigen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-cystine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-cystine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-cystine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in basic amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B(0,+)-type amino acid transporter 1
    Names
    b(0,+)AT
    glycoprotein-associated amino acid transporter b0,+AT1
    solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
    solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053929.1 → NP_446381.1  B(0,+)-type amino acid transporter 1

      See identical proteins and their annotated locations for NP_446381.1

      Status: PROVISIONAL

      Source sequence(s)
      AB029559
      UniProtKB/Swiss-Prot
      P82252, Q4KM04
      UniProtKB/TrEMBL
      A6JAB3
      Related
      ENSRNOP00000016919.2, ENSRNOT00000016919.6
      Conserved Domains (1) summary
      TIGR00911
      Location:13 → 484
      2A0308; L-type amino acid transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      97246253..97269546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759103.4 → XP_008757325.1  B(0,+)-type amino acid transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_008757325.1

      UniProtKB/Swiss-Prot
      P82252, Q4KM04
      UniProtKB/TrEMBL
      A6JAB3
      Conserved Domains (1) summary
      TIGR00911
      Location:13 → 484
      2A0308; L-type amino acid transporter

    2. XM_063266018.1 → XP_063122088.1  B(0,+)-type amino acid transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P82252, Q4KM04
      UniProtKB/TrEMBL
      A6JAB3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82252.1 GenPept UniProtKB/Swiss-Prot:P82252

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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