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    Ptgr3 prostaglandin reductase 3 [ Mus musculus (house mouse) ]

    Gene ID: 225791, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ptgr3provided by MGI
    Official Full Name
    prostaglandin reductase 3provided by MGI
    Primary source
    MGI:MGI:2444835
    See related
    Ensembl:ENSMUSG00000049090 AllianceGenome:MGI:2444835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pthr3; Zadh2; PTGR-3; C530046K17Rik
    Summary
    Enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Involved in negative regulation of fat cell differentiation. Located in peroxisome. Orthologous to human PTGR3 (prostaglandin reductase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 15.8), ovary adult (RPKM 15.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptgr3 in Genome Data Viewer
    Location:
    18 E4; 18 57.53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84106250..84115579)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84088126..84097528)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31792 Neighboring gene teashirt zinc finger family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E11664 Neighboring gene predicted gene, 31854 Neighboring gene STARR-seq mESC enhancer starr_45246 Neighboring gene zinc finger protein 407 Neighboring gene STARR-seq mESC enhancer starr_45247 Neighboring gene predicted gene, 57824

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Predicted mouse peroxisome-targeted proteins and their actual subcellular locations. Mizuno Y, et al. BMC Bioinformatics, 2008 Dec 12. PMID 19091015, Free PMC Article
    2. Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity. Yu YH, et al. J Lipid Res, 2013 Sep. PMID 23821743, Free PMC Article
    3. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC32469

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prostaglandin reductase-3
    Names
    15-oxoprostaglandin 13-reductase
    zinc binding alcohol dehydrogenase, domain containing 2
    zinc-binding alcohol dehydrogenase domain-containing protein 2
    NP_001404766.1
    NP_001404768.1
    NP_001404769.1
    NP_666202.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417837.1 → NP_001404766.1  prostaglandin reductase-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124012

    2. NM_001417839.1 → NP_001404768.1  prostaglandin reductase-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124012

    3. NM_001417840.1 → NP_001404769.1  prostaglandin reductase-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124012
      UniProtKB/TrEMBL
      A0A494BB38
      Related
      ENSMUSP00000158299.2, ENSMUST00000235383.2

    4. NM_146090.6 → NP_666202.2  prostaglandin reductase-3 isoform 1

      See identical proteins and their annotated locations for NP_666202.2

      Status: VALIDATED

      Source sequence(s)
      AC124012
      Consensus CDS
      CCDS29381.1
      UniProtKB/Swiss-Prot
      Q8BGC4
      UniProtKB/TrEMBL
      Q14AZ9
      Related
      ENSMUSP00000052544.3, ENSMUST00000060223.4
      Conserved Domains (2) summary
      cd08250
      Location:32 → 368
      Mgc45594_like; Mgc45594 gene product and other MDR family members
      COG0604
      Location:33 → 368
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      84106250..84115579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGC4.1 GenPept UniProtKB/Swiss-Prot:Q8BGC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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