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    Rbm4b RNA binding motif protein 4B [ Mus musculus (house mouse) ]

    Gene ID: 66704, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Rbm4bprovided by MGI
    Official Full Name
    RNA binding motif protein 4Bprovided by MGI
    Primary source
    MGI:MGI:1913954
    See related
    Ensembl:ENSMUSG00000033760 AllianceGenome:MGI:1913954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lark2; Neosin; 4921506I22Rik
    Summary
    Predicted to enable RNA binding activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and regulation of translation. Acts upstream of or within positive regulation of gene expression. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nuclear speck. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human RBM4B (RNA binding motif protein 4B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in testis adult (RPKM 17.3), CNS E14 (RPKM 10.5) and 26 other tissues See more
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    Genomic context

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    See Rbm4b in Genome Data Viewer
    Location:
    19 A; 19 4.11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4806480..4816199)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4756452..4765946)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene predicted gene 21992 Neighboring gene STARR-positive B cell enhancer ABC_E1967 Neighboring gene STARR-seq mESC enhancer starr_45357 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45358 Neighboring gene RNA binding motif protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M. Su CH, et al. Mol Cell Biol, 2017 Feb 1. PMID 27821480, Free PMC Article
    2. RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression. Tarn WY, et al. Mol Biol Cell, 2016 May 15. PMID 27009199, Free PMC Article
    3. Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency. Tsai YY, et al. Commun Biol, 2023 Sep 5. PMID 37670183, Free PMC Article
    4. LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1. Kojima S, et al. Proc Natl Acad Sci U S A, 2007 Feb 6. PMID 17264215, Free PMC Article
    5. Phylogenetic and molecular characterization of the splicing factor RBM4. Lu CC, et al. PLoS One, 2013. PMID 23527094, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC115931

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in circadian rhythm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in entrainment of circadian clock by photoperiod IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 4B
    Names
    RNA-binding motif protein 30
    RNA-binding protein 30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025717.3 → NP_079993.2  RNA-binding protein 4B

      Status: VALIDATED

      Source sequence(s)
      AW475895, BC019488, BF782018
      Consensus CDS
      CCDS29435.1
      UniProtKB/Swiss-Prot
      Q8VE92
      Related
      ENSMUSP00000038256.7, ENSMUST00000036744.8
      Conserved Domains (4) summary
      PTZ00368
      Location:145 → 181
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      smart00343
      Location:161 → 176
      ZnF_C2HC; zinc finger
      cd12606
      Location:2 → 68
      RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
      cd12607
      Location:78 → 144
      RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4806480..4816199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531824.5 → XP_006531887.1  RNA-binding protein 4B isoform X1

      UniProtKB/Swiss-Prot
      Q8VE92
      Conserved Domains (4) summary
      PTZ00368
      Location:145 → 181
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      smart00343
      Location:161 → 176
      ZnF_C2HC; zinc finger
      cd12606
      Location:2 → 68
      RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
      cd12607
      Location:78 → 144
      RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

    2. XM_006531825.5 → XP_006531888.1  RNA-binding protein 4B isoform X1

      UniProtKB/Swiss-Prot
      Q8VE92
      Conserved Domains (4) summary
      PTZ00368
      Location:145 → 181
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      smart00343
      Location:161 → 176
      ZnF_C2HC; zinc finger
      cd12606
      Location:2 → 68
      RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
      cd12607
      Location:78 → 144
      RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

    3. XM_006531827.5 → XP_006531890.1  RNA-binding protein 4B isoform X2

      UniProtKB/TrEMBL
      A0A494B9C0, A0A494BAP6
      Related
      ENSMUSP00000157577.2, ENSMUST00000236797.2
      Conserved Domains (1) summary
      cl17169
      Location:2 → 68
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_030251030.2 → XP_030106890.1  RNA-binding protein 4B isoform X1

      UniProtKB/Swiss-Prot
      Q8VE92
      Conserved Domains (4) summary
      PTZ00368
      Location:145 → 181
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      smart00343
      Location:161 → 176
      ZnF_C2HC; zinc finger
      cd12606
      Location:2 → 68
      RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
      cd12607
      Location:78 → 144
      RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

    5. XM_006531826.4 → XP_006531889.1  RNA-binding protein 4B isoform X1

      UniProtKB/Swiss-Prot
      Q8VE92
      Conserved Domains (4) summary
      PTZ00368
      Location:145 → 181
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      smart00343
      Location:161 → 176
      ZnF_C2HC; zinc finger
      cd12606
      Location:2 → 68
      RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
      cd12607
      Location:78 → 144
      RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

    RNA

    1. XR_001782610.2 RNA Sequence

    2. XR_003952808.1 RNA Sequence

    3. XR_003952803.1 RNA Sequence

    4. XR_001782611.3 RNA Sequence

    5. XR_003952806.2 RNA Sequence

    6. XR_003952809.2 RNA Sequence

    7. XR_003952805.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE92.1 GenPept UniProtKB/Swiss-Prot:Q8VE92

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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