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    Fcgbpl1 Fc fragment of IgG binding protein like 1 [ Mus musculus (house mouse) ]

    Gene ID: 319482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fcgbpl1provided by MGI
    Official Full Name
    Fc fragment of IgG binding protein like 1provided by MGI
    Primary source
    MGI:MGI:2442118
    See related
    Ensembl:ENSMUSG00000078776 AllianceGenome:MGI:2442118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FCGBP; 9530053A07Rik
    Summary
    Predicted to be active in extracellular matrix and extracellular space. Orthologous to human FCGBP (Fc gamma binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 46.8), large intestine adult (RPKM 37.9) and 4 other tissues See more
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    Genomic context

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    See Fcgbpl1 in Genome Data Viewer
    Location:
    7 A3; 7 16.54 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27828891..27864236)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28129466..28164811)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Fc fragment of IgG binding protein Neighboring gene tectorin alpha pseudogene Neighboring gene predicted gene, 38976 Neighboring gene predicted gene, 24356 Neighboring gene STARR-seq mESC enhancer starr_18401 Neighboring gene STARR-seq mESC enhancer starr_18402 Neighboring gene STARR-positive B cell enhancer ABC_E6526 Neighboring gene predicted gene, 31024 Neighboring gene fibrillarin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. Johansson ME, et al. J Proteome Res, 2009 Jul. PMID 19432394
    2. Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction. Yang W, et al. Cell Chem Biol, 2023 Oct 19. PMID 37442135
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fc fragment of IgG binding protein like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164655.1 → NP_001158127.1  Fc fragment of IgG binding protein like 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AC141883, AC158220
      Consensus CDS
      CCDS52160.1
      UniProtKB/TrEMBL
      E9PVG8
      Related
      ENSMUSP00000056479.5, ENSMUST00000059886.12
      Conserved Domains (7) summary
      smart00216
      Location:828 → 988
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1033 → 1108
      C8; This domain contains 8 conserved cysteine residues
      pfam00094
      Location:56 → 212
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1916 → 1969
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:644 → 714
      C8; C8 domain
      cl02516
      Location:2404 → 2558
      VWD; von Willebrand factor type D domain
      cl17735
      Location:773 → 827
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27828891..27864236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176924.4: Suppressed sequence

      Description
      NM_176924.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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