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    Leprotl1 leptin receptor overlapping transcript-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 68192, updated on 27-Nov-2024

    Summary

    Official Symbol
    Leprotl1provided by MGI
    Official Full Name
    leptin receptor overlapping transcript-like 1provided by MGI
    Primary source
    MGI:MGI:1915442
    See related
    Ensembl:ENSMUSG00000031513 AllianceGenome:MGI:1915442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110067H13Rik; 1520402O14Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and negative regulation of growth hormone receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endosome. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human LEPROTL1 (leptin receptor overlapping transcript like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 30.5), whole brain E14.5 (RPKM 19.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Leprotl1 in Genome Data Viewer
    Location:
    8 A4; 8 20.9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34602726..34613893, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (34135572..34146739, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene membrane bound O-acyltransferase domain containing 4 Neighboring gene ERH mRNA splicing and mitosis factor retrotransposed, pseudogene Neighboring gene predicted gene, 39158 Neighboring gene STARR-positive B cell enhancer mm9_chr8:35217440-35217740 Neighboring gene STARR-positive B cell enhancer ABC_E10495 Neighboring gene store-operated calcium entry-associated regulatory factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:35226466-35226653 Neighboring gene microRNA 6395 Neighboring gene predicted gene, 33638

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leptin receptor overlapping transcript-like 1
    Names
    endospanin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026609.2NP_080885.1  leptin receptor overlapping transcript-like 1

      See identical proteins and their annotated locations for NP_080885.1

      Status: VALIDATED

      Source sequence(s)
      BC004677
      Consensus CDS
      CCDS22239.1
      UniProtKB/Swiss-Prot
      Q3U662, Q9CQ74
      UniProtKB/TrEMBL
      Q3U3K5
      Related
      ENSMUSP00000033910.9, ENSMUST00000033910.9
      Conserved Domains (1) summary
      pfam04133
      Location:7124
      Vps55; Vacuolar protein sorting 55

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      34602726..34613893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)