Esp1 exocrine gland secreted peptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esp1provided by MGI
Official Full Name: exocrine gland secreted peptide 1provided by MGI
Primary source: MGI:MGI:3645915
See related: Ensembl:ENSMUSG00000073396 AllianceGenome:MGI:3645915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm6084; EG619517
Summary: Enables pheromone activity. Acts upstream of or within positive regulation of female receptivity. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 17 B2; 17 19.54 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (41038011..41042673)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (40727120..40731782)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The male pheromone exocrine gland-secreting peptide 1 (ESP1) is one of the key factors that causes pregnancy block. Female mice exhibited high pregnancy failure rates upon encountering males that secreted different levels of ESP1 compared to the mated male.
Title: Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal Responsible for the Bruce Effect in Mice.
charge-charge interactions determine the specificity of ESP1 binding to V2Rp5 in the large extracellular region characteristic of class C GPCRs.
Title: Structure of the mouse sex peptide pheromone ESP1 reveals a molecular basis for specific binding to the class C G-protein-coupled vomeronasal receptor.
ESP1 is a crucial male pheromone that regulates female reproductive behaviour through a specific receptor in the mouse vomeronasal system.
Title: The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor.
identification of a male-specific 7-kDa peptide secreted from the extraorbital lacrimal gland; ESP1 is secreted from the eyes and is transferred to the female vomeronasal organ, where it stimulates pheromone receptor-expressing vomeronasal sensory neurons
Title: Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

D17Mit104 (e-PCR), detects polymorphism
- UniSTS:127941

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables pheromone activity	IDA Inferred from Direct Assay more info	PubMed
enables pheromone activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of female receptivity	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: exocrine gland-secreted peptide 1

Names: exocrine gland-secreting peptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.