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    Trappc10 trafficking protein particle complex 10 [ Mus musculus (house mouse) ]

    Gene ID: 216131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trappc10provided by MGI
    Official Full Name
    trafficking protein particle complex 10provided by MGI
    Primary source
    MGI:MGI:1336209
    See related
    Ensembl:ENSMUSG00000000374 AllianceGenome:MGI:1336209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm870; Tmem1; b2b2416Clo; b2b2613Clo; B230307C21Rik
    Summary
    Predicted to be involved in early endosome to Golgi transport and intra-Golgi vesicle-mediated transport. Predicted to be part of TRAPPII protein complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study agnathia-otocephaly complex and velocardiofacial syndrome. Orthologous to human TRAPPC10 (trafficking protein particle complex subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 30.2), large intestine adult (RPKM 27.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trappc10 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78021256..78080479, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78185422..78244645, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6877 Neighboring gene glutamine amidotransferase like class 1 domain containing 3A Neighboring gene STARR-seq mESC enhancer starr_27217 Neighboring gene PWP2 periodic tryptophan protein homolog (yeast) Neighboring gene STARR-seq mESC enhancer starr_27219 Neighboring gene predicted gene, 30122 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3894 Neighboring gene STARR-seq mESC enhancer starr_27222 Neighboring gene microRNA 7659

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice. Rawlins LE, et al. PLoS Genet, 2022 Mar. PMID 35298461, Free PMC Article
    2. Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Wang J, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716696, Free PMC Article
    3. Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice. Hu M, et al. Int J Biol Sci, 2023. PMID 37416774, Free PMC Article
    4. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article
    5. High-resolution comparative physical mapping of mouse chromosome 10 in the region of homology with human chromosome 21. Cole SE, et al. Mamm Genome, 1999 Mar. PMID 10051316

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle coating NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle tethering NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPPII protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPPII protein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 10
    Names
    TRAPP subunit TMEM1
    trafficking protein particle complex subunit TMEM1
    transmembrane protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081055.2 → NP_001074524.1  trafficking protein particle complex subunit 10

      See identical proteins and their annotated locations for NP_001074524.1

      Status: VALIDATED

      Source sequence(s)
      AC164573
      Consensus CDS
      CCDS35959.1
      UniProtKB/Swiss-Prot
      F8VQF9, Q3TLI0, Q811H4
      Related
      ENSMUSP00000000384.7, ENSMUST00000000384.8
      Conserved Domains (1) summary
      pfam12584
      Location:1067 → 1245
      TRAPPC10; Trafficking protein particle complex subunit 10, TRAPPC10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      78021256..78080479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245014.2 → XP_030100874.1  trafficking protein particle complex subunit 10 isoform X1

      Conserved Domains (1) summary
      pfam12584
      Location:828 → 1054
      TRAPPC10; Trafficking protein particle complex subunit 10, TRAPPC10
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TLI0.3 GenPept UniProtKB/Swiss-Prot:Q3TLI0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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