Supt16 SPT16, facilitates chromatin remodeling subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Supt16provided by MGI
Official Full Name: SPT16, facilitates chromatin remodeling subunitprovided by MGI
Primary source: MGI:MGI:1890948
See related: Ensembl:ENSMUSG00000035726 AllianceGenome:MGI:1890948
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdc68; Spt16; Fact140; Supt16h
Summary: Predicted to enable nucleosome binding activity. Predicted to be involved in nucleosome disassembly and transcription elongation by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of FACT complex. Is expressed in several structures, including alimentary system; brain; hindlimb phalanx; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 42.5), liver E14 (RPKM 20.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 26.83 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (52397876..52434696, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (52160419..52197239, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Supt16 haploinsufficiency causes neurodevelopment disorder by disrupting MAPK pathway in neural stem cells.
Title: Supt16 haploinsufficiency causes neurodevelopment disorder by disrupting MAPK pathway in neural stem cells.
Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
Title: Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage.
Title: Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability.
The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus
Title: The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Supt16h (e-PCR), detects polymorphism
- UniSTS:547376

RH138387 (e-PCR)
- UniSTS:220474

D14Dcr2 (e-PCR), detects polymorphism
- UniSTS:507499

D14Mit233 (e-PCR), detects polymorphism
- UniSTS:127348

BB284418 (e-PCR)
- UniSTS:209025

WI-14045 (e-PCR)
- UniSTS:39614

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in nucleosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FACT complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FACT complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: FACT complex subunit SPT16

Names: FACT 140 kDa subunit; FACTp140; chromatin-specific transcription elongation factor 140 kDa subunit; facilitates chromatin transcription complex subunit SPT16; suppressor of Ty 16 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.