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    Map3k21 mitogen-activated protein kinase kinase kinase 21 [ Mus musculus (house mouse) ]

    Gene ID: 234878, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Map3k21provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 21provided by MGI
    Primary source
    MGI:MGI:2385307
    See related
    Ensembl:ENSMUSG00000031853 AllianceGenome:MGI:2385307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlk4; mKIAA1804
    Summary
    Predicted to enable JUN kinase kinase kinase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in ovary and testis. Orthologous to human MAP3K21 (mitogen-activated protein kinase kinase kinase 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 9.7), large intestine adult (RPKM 6.1) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map3k21 in Genome Data Viewer
    Location:
    8 E2; 8 73.65 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (126637189..126674179)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (125910450..125947440)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 2 Neighboring gene predicted gene, 46061 Neighboring gene STARR-seq mESC enhancer starr_23048 Neighboring gene STARR-seq mESC enhancer starr_23049 Neighboring gene RIKEN cDNA A730098A19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:128474175-128474476 Neighboring gene predicted gene, 31069 Neighboring gene predicted gene, 42056

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MLK4 has negative effect on TLR4 signaling. Seit-Nebi A, et al. Cell Mol Immunol, 2012 Jan. PMID 21602844, Free PMC Article
    2. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Bouma GJ, et al. Biol Reprod, 2010 Feb. PMID 19864314, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MLK4 is a negative regulator of TLR4 signaling.
      Title: MLK4 has negative effect on TLR4 signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • KIAA1804, MGC27778

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables JUN kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 21
    Names
    mitogen-activated protein kinase kinase kinase MLK4
    mixed lineage kinase 4
    NP_663583.2
    XP_006531034.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145608.2 → NP_663583.2  mitogen-activated protein kinase kinase kinase 21

      See identical proteins and their annotated locations for NP_663583.2

      Status: VALIDATED

      Source sequence(s)
      AC102420, AC105066
      Consensus CDS
      CCDS40519.1
      UniProtKB/Swiss-Prot
      Q5DTU6, Q811F5, Q8VDG6
      Related
      ENSMUSP00000034316.5, ENSMUST00000034316.6
      Conserved Domains (3) summary
      smart00219
      Location:110 → 382
      TyrKc; Tyrosine kinase, catalytic domain
      cl17036
      Location:28 → 82
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:115 → 385
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      126637189..126674179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530971.1 → XP_006531034.1  mitogen-activated protein kinase kinase kinase 21 isoform X1

      Conserved Domains (1) summary
      TIGR03319
      Location:3 → 81
      RNase_Y; ribonuclease Y
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDG6.2 GenPept UniProtKB/Swiss-Prot:Q8VDG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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