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    Myh15 myosin, heavy chain 15 [ Mus musculus (house mouse) ]

    Gene ID: 667772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myh15provided by MGI
    Official Full Name
    myosin, heavy chain 15provided by MGI
    Primary source
    MGI:MGI:3643515
    See related
    Ensembl:ENSMUSG00000092009 AllianceGenome:MGI:3643515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG667772
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in extrinsic ocular muscle. Orthologous to human MYH15 (myosin heavy chain 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.0), frontal lobe adult (RPKM 0.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myh15 in Genome Data Viewer
    Location:
    16 B5; 16 30.75 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48877763..49019926)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (49057400..49199563)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DAZ interacting protein 3, zinc finger Neighboring gene predicted gene, 22576 Neighboring gene STARR-seq mESC enhancer starr_40963 Neighboring gene STARR-seq mESC enhancer starr_40964 Neighboring gene cell proliferation regulating inhibitor of protein phosphatase 2A Neighboring gene STARR-positive B cell enhancer mm9_chr16:49164447-49164748 Neighboring gene RIKEN cDNA 1700026J12 gene Neighboring gene predicted gene 5407

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles. Rossi AC, et al. J Physiol, 2010 Jan 15. PMID 19948655, Free PMC Article
    2. Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Sambasivan R, et al. Dev Cell, 2009 Jun. PMID 19531352
    3. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166210.2 → NP_001159682.1  myosin-15

      Status: VALIDATED

      Source sequence(s)
      AC116470, AC122233, AC154447
      Consensus CDS
      CCDS49868.1
      UniProtKB/TrEMBL
      E9Q264
      Related
      ENSMUSP00000127539.2, ENSMUST00000168680.2
      Conserved Domains (5) summary
      cd14929
      Location:96 → 757
      MYSc_Myh15_mammals; class II myosin heavy chain 15, motor domain
      pfam00063
      Location:84 → 757
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:838 → 1914
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:31 → 69
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam08537
      Location:1004 → 1136
      NBP1; Fungal Nap binding protein NBP1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      48877763..49019926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249245.2 → XP_030105105.2  myosin-15 isoform X1

      Conserved Domains (2) summary
      pfam01576
      Location:709 → 1785
      Myosin_tail_1; Myosin tail
      cl22853
      Location:1 → 628
      Motor_domain; Myosin and Kinesin motor domain
    Nucleotide Protein
    Heading Accession and Version

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