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    Galr2 galanin receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 14428, updated on 9-Dec-2024

    Summary

    Official Symbol
    Galr2provided by MGI
    Official Full Name
    galanin receptor 2provided by MGI
    Primary source
    MGI:MGI:1337018
    See related
    Ensembl:ENSMUSG00000020793 AllianceGenome:MGI:1337018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mGalR
    Summary
    Predicted to enable galanin receptor activity; neuropeptide binding activity; and peptide hormone binding activity. Acts upstream of or within neuron projection development. Predicted to be located in cilium. Predicted to be active in plasma membrane. Orthologous to human GALR2 (galanin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 4.8), colon adult (RPKM 3.3) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Galr2 in Genome Data Viewer
    Location:
    11 E2; 11 81.1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116170520..116174776)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116280106..116283950)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene envoplakin Neighboring gene predicted gene, 33250 Neighboring gene signal recognition particle 68 Neighboring gene STARR-positive B cell enhancer ABC_E9847 Neighboring gene exocyst complex component 7 Neighboring gene STARR-positive B cell enhancer ABC_E7099 Neighboring gene predicted gene, 26730

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC151357, MGC151359

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables galanin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables galanin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables galanin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neuropeptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in galanin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inositol phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inositol phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of large conductance calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    galanin receptor type 2
    Names
    GAL2-R
    GALR-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010254.4 → NP_034384.3  galanin receptor type 2

      See identical proteins and their annotated locations for NP_034384.3

      Status: VALIDATED

      Source sequence(s)
      AK053776, AW046646, BC116982
      Consensus CDS
      CCDS25663.1
      UniProtKB/Swiss-Prot
      O88854, Q14A53, Q9Z2B0
      UniProtKB/TrEMBL
      Q8BKB0
      Related
      ENSMUSP00000054062.3, ENSMUST00000055872.3
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 291
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:31 → 305
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116170520..116174776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248727.4 → XP_011247029.1  galanin receptor type 2 isoform X1

      UniProtKB/TrEMBL
      Q8BKB0
      Conserved Domains (1) summary
      cd15097
      Location:25 → 302
      7tmA_Gal2_Gal3_R; galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors