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    Tulp2 TUB like protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 56734, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Tulp2provided by MGI
    Official Full Name
    TUB like protein 2provided by MGI
    Primary source
    MGI:MGI:1861600
    See related
    Ensembl:ENSMUSG00000023467 AllianceGenome:MGI:1861600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdet
    Summary
    Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in protein localization to cilium. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in cilium. Is expressed in urogenital ridge. Orthologous to human TULP2 (TUB like protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 195.7) See more
    Orthologs
    human all
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    Genomic context

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    See Tulp2 in Genome Data Viewer
    Location:
    7 B3; 7 29.33 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45131450..45173070)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45482026..45523646)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18840 Neighboring gene STARR-seq mESC enhancer starr_18841 Neighboring gene ferritin light polypeptide 1 Neighboring gene BCL2-associated X protein Neighboring gene dihydrodiol dehydrogenase Neighboring gene nucleobindin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2239 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52781513-52781717 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene predicted gene, 53387 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene STARR-seq mESC enhancer starr_18846

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility. Oyama Y, et al. Reprod Med Biol, 2022 Jan-Dec. PMID 35619658, Free PMC Article
    2. Identification and characterization of the developmentally regulated pattern of expression in the testis of a mouse gene exhibiting similarity to the family of phosphodiesterases. Vambutas V, et al. Biochim Biophys Acta, 1994 Mar 1. PMID 7509194
    3. The tubby family proteins. Mukhopadhyay S, et al. Genome Biol, 2011 Jun 28. PMID 21722349, Free PMC Article
    4. TULP2, a New RNA-Binding Protein, Is Required for Mouse Spermatid Differentiation and Male Fertility. Zheng M, et al. Front Cell Dev Biol, 2021. PMID 33763418, Free PMC Article
    5. Cell-specific expression of tubby gene family members (tub, Tulp1,2, and 3) in the retina. Ikeda S, et al. Invest Ophthalmol Vis Sci, 1999 Oct. PMID 10509669

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107290

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphoric diester hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubby-related protein 2
    Names
    protein P4-6
    testis specific phosphodiesterase
    tubby-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045555.2 → NP_001039020.1  tubby-related protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001039020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. The resulting isoform (2) is the same length but has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK054304, AK077200, BY087813
      Consensus CDS
      CCDS39953.1
      UniProtKB/Swiss-Prot
      P46686, Q3TTV1, Q5FW93, Q8C5R7, Q8C5R9, Q9R1I8
      Related
      ENSMUSP00000103391.2, ENSMUST00000107762.10
      Conserved Domains (2) summary
      pfam01167
      Location:315 → 555
      Tub; Tub family
      pfam16322
      Location:39 → 264
      Tub_N; Tubby N-terminal

    2. NM_001290996.2 → NP_001277925.1  tubby-related protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 2. The resulting isoform (3) contains an alternate internal segment and is shorter at the N-terminus compared to isoform 2.
      Source sequence(s)
      AC151602, AK054304
      Consensus CDS
      CCDS71961.1
      UniProtKB/TrEMBL
      A0A1B0GRN6
      Related
      ENSMUSP00000147596.2, ENSMUST00000210813.2
      Conserved Domains (2) summary
      pfam01167
      Location:203 → 450
      Tub; Tub family
      pfam16322
      Location:6 → 152
      Tub_N; Tubby N-terminal

    3. NM_001290998.2 → NP_001277927.1  tubby-related protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001277927.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (4) is shorter at the N-terminus and has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC151602, BC089545
      Consensus CDS
      CCDS80720.1
      UniProtKB/Swiss-Prot
      P46686
      Related
      ENSMUSP00000082438.6, ENSMUST00000085331.14
      Conserved Domains (1) summary
      pfam01167
      Location:191 → 431
      Tub; Tub family

    4. NM_001290999.2 → NP_001277928.1  tubby-related protein 2 isoform 5

      See identical proteins and their annotated locations for NP_001277928.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (5) is shorter at the N-terminus and has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC151602, AK161165
      Consensus CDS
      CCDS71960.1
      UniProtKB/Swiss-Prot
      P46686
      Related
      ENSMUSP00000103388.2, ENSMUST00000107759.10
      Conserved Domains (1) summary
      pfam01167
      Location:203 → 445
      Tub; Tub family

    5. NM_008807.3 → NP_032833.2  tubby-related protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (1) is the same length but has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC151602, BB617192, BC048740, BY087813
      Consensus CDS
      CCDS39954.1
      UniProtKB/Swiss-Prot
      P46686
      Related
      ENSMUSP00000024233.7, ENSMUST00000024233.15
      Conserved Domains (2) summary
      pfam01167
      Location:315 → 555
      Tub; Tub family
      pfam16322
      Location:39 → 264
      Tub_N; Tubby N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45131450..45173070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541020.2 → XP_006541083.1  tubby-related protein 2 isoform X6

      See identical proteins and their annotated locations for XP_006541083.1

      Conserved Domains (2) summary
      pfam01167
      Location:259 → 508
      Tub; Tub family
      pfam16322
      Location:1 → 147
      Tub_N; Tubby N-terminal

    2. XM_036153278.1 → XP_036009171.1  tubby-related protein 2 isoform X6

      Conserved Domains (2) summary
      pfam01167
      Location:259 → 508
      Tub; Tub family
      pfam16322
      Location:1 → 147
      Tub_N; Tubby N-terminal

    3. XM_030242817.2 → XP_030098677.1  tubby-related protein 2 isoform X7

      UniProtKB/TrEMBL
      D3Z0R4
      Conserved Domains (1) summary
      pfam01167
      Location:203 → 452
      Tub; Tub family

    4. XM_006541017.4 → XP_006541080.2  tubby-related protein 2 isoform X2

      Conserved Domains (3) summary
      pfam01167
      Location:315 → 564
      Tub; Tub family
      pfam06658
      Location:17 → 53
      DUF1168; Protein of unknown function (DUF1168)
      pfam16322
      Location:39 → 199
      Tub_N; Tubby N-terminal

    5. XM_006541016.3 → XP_006541079.2  tubby-related protein 2 isoform X1

      Conserved Domains (3) summary
      pfam01167
      Location:315 → 564
      Tub; Tub family
      pfam06658
      Location:17 → 53
      DUF1168; Protein of unknown function (DUF1168)
      pfam16322
      Location:39 → 199
      Tub_N; Tubby N-terminal

    6. XM_006541019.4 → XP_006541082.2  tubby-related protein 2 isoform X4

      Conserved Domains (3) summary
      pfam01167
      Location:298 → 547
      Tub; Tub family
      pfam06658
      Location:17 → 53
      DUF1168; Protein of unknown function (DUF1168)
      pfam16322
      Location:39 → 199
      Tub_N; Tubby N-terminal

    7. XM_006541018.4 → XP_006541081.2  tubby-related protein 2 isoform X3

      Conserved Domains (2) summary
      pfam01167
      Location:304 → 553
      Tub; Tub family
      pfam16322
      Location:28 → 188
      Tub_N; Tubby N-terminal

    8. XM_006541022.2 → XP_006541085.1  tubby-related protein 2 isoform X7

      See identical proteins and their annotated locations for XP_006541085.1

      UniProtKB/TrEMBL
      D3Z0R4
      Conserved Domains (1) summary
      pfam01167
      Location:203 → 452
      Tub; Tub family

    9. XM_030242816.2 → XP_030098676.1  tubby-related protein 2 isoform X5

      Conserved Domains (2) summary
      pfam01167
      Location:304 → 546
      Tub; Tub family
      pfam16322
      Location:28 → 188
      Tub_N; Tubby N-terminal

    10. XM_030242818.1 → XP_030098678.1  tubby-related protein 2 isoform X8

      Conserved Domains (1) summary
      pfam01167
      Location:203 → 445
      Tub; Tub family

    11. XM_036153279.1 → XP_036009172.1  tubby-related protein 2 isoform X7

      UniProtKB/TrEMBL
      D3Z0R4
      Related
      ENSMUSP00000103387.4, ENSMUST00000107758.10
      Conserved Domains (1) summary
      pfam01167
      Location:203 → 452
      Tub; Tub family

    12. XM_006541025.4 → XP_006541088.1  tubby-related protein 2 isoform X9

      UniProtKB/Swiss-Prot
      P46686
      Related
      ENSMUSP00000147710.2, ENSMUST00000210868.2
      Conserved Domains (1) summary
      pfam01167
      Location:203 → 445
      Tub; Tub family

    13. XM_030242819.1 → XP_030098679.1  tubby-related protein 2 isoform X8

      Conserved Domains (1) summary
      pfam01167
      Location:203 → 445
      Tub; Tub family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46686.3 GenPept UniProtKB/Swiss-Prot:P46686

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