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    Eif3h eukaryotic translation initiation factor 3, subunit H [ Mus musculus (house mouse) ]

    Gene ID: 68135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif3hprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Hprovided by MGI
    Primary source
    MGI:MGI:1915385
    See related
    Ensembl:ENSMUSG00000022312 AllianceGenome:MGI:1915385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    40kD; Eif3s3; EIF3-P40; EIF3-gamma; 1110008A16Rik; 9430017H16Rik
    Summary
    Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in several structures, including central nervous system; early conceptus; oocyte; sensory organ; and upper jaw. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 124.1), CNS E14 (RPKM 118.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif3h in Genome Data Viewer
    Location:
    15 C; 15 19.42 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (51649956..51728901, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (51786563..51865461, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38649 Neighboring gene predicted gene, 34503 Neighboring gene STARR-seq mESC enhancer starr_38651 Neighboring gene predicted gene, 41320 Neighboring gene STARR-seq mESC enhancer starr_38653 Neighboring gene STARR-positive B cell enhancer ABC_E4132 Neighboring gene STARR-positive B cell enhancer ABC_E5475 Neighboring gene predicted gene, 34678 Neighboring gene UTP23 small subunit processome component Neighboring gene predicted gene, 48923

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit H (eIF3h), as an enhancer of variegation in the mouse. Daxinger L, et al. G3 (Bethesda), 2012 Nov. PMID 23173090, Free PMC Article
    2. Mouse p56 blocks a distinct function of eukaryotic initiation factor 3 in translation initiation. Hui DJ, et al. J Biol Chem, 2005 Feb 4. PMID 15561726
    3. The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression. Jin H, et al. Nat Commun, 2024 Mar 21. PMID 38514606, Free PMC Article
    4. Unveiling dysregulated lncRNAs and networks in non-syndromic cleft lip with or without cleft palate pathogenesis. Wu C, et al. Sci Rep, 2024 Jan 10. PMID 38200098, Free PMC Article
    5. A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice. Fantauzzo KA, et al. Hum Mol Genet, 2008 Nov 15. PMID 18713754, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identified of the first two alleles of eIF3h in an unbiased forward genetic screen for modifiers of epigenetic reprogramming in the mouse.
      Title: A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit H (eIF3h), as an enhancer of variegation in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107627

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal-dependent deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal-dependent deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic 43S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit H
    Names
    eIF3 p40 subunit
    eukaryotic translation initiation factor 3 subunit 3
    eukaryotic translation initiation factor 3, subunit 3 (gamma)
    eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418513.1 → NP_001405442.1  eukaryotic translation initiation factor 3 subunit H isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102229
      UniProtKB/TrEMBL
      Q3THW7, Q3TII2, Q8BTX5

    2. NM_001418514.1 → NP_001405443.1  eukaryotic translation initiation factor 3 subunit H isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102229
      UniProtKB/TrEMBL
      Q3THW7, Q3TII2, Q8BTX5

    3. NM_001418515.1 → NP_001405444.1  eukaryotic translation initiation factor 3 subunit H isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102229
      UniProtKB/TrEMBL
      Q3THW7, Q3TII2, Q8BTX5

    4. NM_001418516.1 → NP_001405445.1  eukaryotic translation initiation factor 3 subunit H isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC102229
      UniProtKB/TrEMBL
      Q3THW7, Q8BTX5

    5. NM_080635.2 → NP_542366.1  eukaryotic translation initiation factor 3 subunit H isoform 1

      See identical proteins and their annotated locations for NP_542366.1

      Status: VALIDATED

      Source sequence(s)
      AC102229
      Consensus CDS
      CCDS27461.1
      UniProtKB/Swiss-Prot
      Q91WK2
      UniProtKB/TrEMBL
      Q3THW7, Q3TII2, Q5M9L0, Q8BTX5
      Related
      ENSMUSP00000022925.9, ENSMUST00000022925.10
      Conserved Domains (1) summary
      cd08065
      Location:37 → 300
      MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      51649956..51728901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WK2.1 GenPept UniProtKB/Swiss-Prot:Q91WK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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