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    Kiz kizuna centrosomal protein [ Mus musculus (house mouse) ]

    Gene ID: 228730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kizprovided by MGI
    Official Full Name
    kizuna centrosomal proteinprovided by MGI
    Primary source
    MGI:MGI:2684960
    See related
    Ensembl:ENSMUSG00000074749 AllianceGenome:MGI:2684960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm114; Plk1s1; Ncrna00153
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in spindle organization. Located in cytoplasm. Is expressed in central nervous system; gonad; sensory organ; and thyroid gland. Human ortholog(s) of this gene implicated in retinitis pigmentosa 69. Orthologous to human KIZ (kizuna centrosomal protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 20.8), bladder adult (RPKM 4.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kiz in Genome Data Viewer
    Location:
    2 G2; 2 72.63 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (146697743..146812018)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (146855825..146970098)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35433 Neighboring gene STARR-seq mESC enhancer starr_05952 Neighboring gene predicted gene 14114 Neighboring gene predicted gene, 34978 Neighboring gene STARR-positive B cell enhancer ABC_E11165 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene Mki67 (FHA domain) interacting nucleolar phosphoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_05954 Neighboring gene STARR-seq mESC enhancer starr_05956 Neighboring gene STARR-seq mESC enhancer starr_05957 Neighboring gene 5'-3' exoribonuclease 2 Neighboring gene NK2 homeobox 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KIZ/GM114 Balances the NF-ĸB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adaptors. Sun J, et al. Front Cell Dev Biol, 2022. PMID 35433693, Free PMC Article
    2. Whole-exome sequencing identifies KIZ as a ciliary gene associated with autosomal-recessive rod-cone dystrophy. El Shamieh S, et al. Am J Hum Genet, 2014 Apr 3. PMID 24680887, Free PMC Article
    3. Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. Tang H, et al. Dev Biol, 2008 Jun 1. PMID 18423593, Free PMC Article
    4. Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. Cook MS, et al. Development, 2011 Jan. PMID 21115610, Free PMC Article
    5. The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. Krentz AD, et al. Proc Natl Acad Sci U S A, 2009 Dec 29. PMID 20007774, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.
      Title: Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein kizuna
    Names
    polo-like kinase 1 substrate 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033298.4 → NP_001028470.1  centrosomal protein kizuna

      See identical proteins and their annotated locations for NP_001028470.1

      Status: VALIDATED

      Source sequence(s)
      AK135486, AL929215
      Consensus CDS
      CCDS16832.1
      UniProtKB/Swiss-Prot
      A2AUS7, B2RX19, Q3UXL4
      Related
      ENSMUSP00000096884.3, ENSMUST00000099278.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      146697743..146812018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161421.1 → XP_036017314.1  centrosomal protein kizuna isoform X1

    2. XM_036161424.1 → XP_036017317.1  centrosomal protein kizuna isoform X3

    3. XM_006499298.4 → XP_006499361.1  centrosomal protein kizuna isoform X2

    4. XM_030250542.2 → XP_030106402.1  centrosomal protein kizuna isoform X4

    RNA

    1. XR_004940113.1 RNA Sequence

    2. XR_004940114.1 RNA Sequence

    3. XR_004940116.1 RNA Sequence

    4. XR_003952536.2 RNA Sequence

    5. XR_004940115.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UXL4.1 GenPept UniProtKB/Swiss-Prot:Q3UXL4

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