Kirrel2 kirre like nephrin family adhesion molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kirrel2provided by MGI
Official Full Name: kirre like nephrin family adhesion molecule 2provided by MGI
Primary source: MGI:MGI:2442334
See related: Ensembl:ENSMUSG00000036915 AllianceGenome:MGI:2442334
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NLG1; NEPH3; C330019F22Rik
Summary: Enables identical protein binding activity. Acts upstream of or within cell-cell adhesion and negative regulation of protein phosphorylation. Located in plasma membrane and slit diaphragm. Is expressed in several structures, including central nervous system; foregut-midgut junction; genitourinary system; sensory organ; and spleen. Orthologous to human KIRREL2 (kirre like nephrin family adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 1.4), CNS E11.5 (RPKM 1.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 18.36 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30146955..30160105, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30447766..30457515, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.
Title: Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.
Kirrel2 is required for axonal coalescence in subsets of Olfactory sensory neurons that project axons to the DII (dorsal) region; Kirrel2/3-independent mechanisms also control olfactory sensory neurons axonal coalescence in certain regions of the Olfactory bulb.
Title: Kirrel2 is differentially required in populations of olfactory sensory neurons for the targeting of axons in the olfactory bulb.
The results of this study demonstrate that Kirrel2 and Kirrel3 are essential for the formation of glomeruli and suggest they contribute to synaptogenesis in the accessory olfactory bulb.
Title: Loss of Kirrel family members alters glomerular structure and synapse numbers in the accessory olfactory bulb.
Kirrel2 expression is directly and rapidly increased by odor stimulation of mouse olfactory sensory neurons. [Kirrel2]
Title: Activity-dependent genes in mouse olfactory sensory neurons.
results show that in pancreatic beta-cells Kirrel2 localizes to adherens junctions, is regulated by multiple post-translational events, including glycosylation, extracellular cleavage, and phosphorylation, and engages in regulation of basal insulin secretion
Title: Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion.
Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken.
Title: Comparative analysis of Neph gene expression in mouse and chicken development.
Nephrin and Neph3 might regulate certain developmental aspects of Ptf1a-positive neurons as homo- or heterooligomers.
Title: Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in slit diaphragm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kin of IRRE-like protein 2

Names: X kin of IRRE like 2; kin of IRRE like 2; kin of irregular chiasm-like 2; kin of irregular chiasm-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172898.3 → NP_766486.1 kin of IRRE-like protein 2 precursor

See identical proteins and their annotated locations for NP_766486.1

Status: PROVISIONAL

Source sequence(s)

AC149067

Consensus CDS

CCDS39883.1

UniProtKB/Swiss-Prot

Q7TQ98, Q7TSU7

UniProtKB/TrEMBL

A0A4X8, B2RXY2

Related

ENSMUSP00000039395.8, ENSMUST00000045817.14

Conserved Domains (4) summary

smart00409
Location:27 → 116

IG; Immunoglobulin

pfam13927
Location:223 → 292

Ig_3; Immunoglobulin domain

cd00096
Location:395 → 399

Ig; Ig strand A [structural motif]

cl11960
Location:394 → 498

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

30146955..30160105 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153095.1 → XP_036008988.1 kin of IRRE-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q7TQ98, Q7TSU7

UniProtKB/TrEMBL

A0A4X8, B2RXY2

Conserved Domains (4) summary

smart00409
Location:27 → 116

IG; Immunoglobulin

pfam13927
Location:223 → 292

Ig_3; Immunoglobulin domain

cd00096
Location:395 → 399

Ig; Ig strand A [structural motif]

cl11960
Location:394 → 498

Ig; Immunoglobulin domain