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    Casp6 caspase 6 [ Mus musculus (house mouse) ]

    Gene ID: 12368, updated on 9-Dec-2024

    Summary

    Official Symbol
    Casp6provided by MGI
    Official Full Name
    caspase 6provided by MGI
    Primary source
    MGI:MGI:1312921
    See related
    Ensembl:ENSMUSG00000027997 AllianceGenome:MGI:1312921
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mch2; CASP-6
    Summary
    This gene encodes a member of the cysteine proteases that plays important roles in regulating apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 36.2), small intestine adult (RPKM 29.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Casp6 in Genome Data Viewer
    Location:
    3 G3; 3 59.5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129695064..129707761)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129901415..129914112)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36180 Neighboring gene complement component factor i Neighboring gene phospholipase A2, group XIIA Neighboring gene predicted gene, 46825 Neighboring gene predicted gene, 40150 Neighboring gene mitochondrial calcium uniporter dominant negative beta subunit Neighboring gene predicted gene, 40151 Neighboring gene SEC24 homolog B, COPII coat complex component Neighboring gene STARR-seq mESC enhancer starr_08982

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables endopeptidase activity PubMed 
    enables endopeptidase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables peptidase activity PubMed 
    enables protein binding PubMed 
    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in activation of innate immune response  
    involved_in activation of innate immune response  
    involved_in acute inflammatory response to non-antigenic stimulus  
    involved_in apoptotic process  
    involved_in axonal fasciculation  
    involved_in cellular response to staurosporine  
    involved_in cellular response to staurosporine  
    involved_in epithelial cell differentiation  
    involved_in hepatocyte apoptotic process  
    involved_in hepatocyte apoptotic process  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of necroptotic process  
    involved_in positive regulation of necroptotic process  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of retinal cell programmed cell death  
    involved_in protein autoprocessing  
    involved_in protein autoprocessing  
    involved_in proteolysis  
    acts_upstream_of_or_within proteolysis PubMed 
    involved_in pyroptotic inflammatory response  
    involved_in pyroptotic inflammatory response  
    acts_upstream_of_or_within regulation of apoptotic process PubMed 
    involved_in regulation of programmed cell death  
    involved_in response to cytokine  
    involved_in response to glucose  
    involved_in response to hydrogen peroxide  
    involved_in response to iron ion  
    Items 1 - 25 of 31
    Component Evidence Code Pubs
    located_in axon  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    caspase-6
    Names
    apoptotic protease Mch-2
    NP_033941.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009811.4NP_033941.3  caspase-6 precursor

      See identical proteins and their annotated locations for NP_033941.3

      Status: REVIEWED

      Source sequence(s)
      AC118620, AK168842, AV048874, BY265671
      Consensus CDS
      CCDS17838.1
      UniProtKB/Swiss-Prot
      O08738
      UniProtKB/TrEMBL
      Q3TPJ9, Q99M47, Q9D089
      Related
      ENSMUSP00000029626.9, ENSMUST00000029626.9
      Conserved Domains (1) summary
      smart00115
      Location:20272
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      129695064..129707761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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