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    Gdi1 GDP dissociation inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 14567, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gdi1provided by MGI
    Official Full Name
    GDP dissociation inhibitor 1provided by MGI
    Primary source
    MGI:MGI:99846
    See related
    Ensembl:ENSMUSG00000015291 AllianceGenome:MGI:99846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GDIA; GDIalpha
    Summary
    Predicted to enable Rab GDP-dissociation inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rab protein signal transduction; negative regulation of protein targeting to membrane; and regulation of axonogenesis. Located in myelin sheath. Is expressed in several structures, including liver; nervous system; placenta; sensory organ; and spleen. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Orthologous to human GDI1 (GDP dissociation inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 251.0), whole brain E14.5 (RPKM 248.0) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Gdi1 in Genome Data Viewer
    Location:
    X A7.3; X 37.97 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73348618..73355473)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74305012..74311867)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 1-like 1 Neighboring gene tafazzin, phospholipid-lysophospholipid transacylase Neighboring gene STARR-positive B cell enhancer ABC_E7694 Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 1 Neighboring gene family with sequence similarity 50, member A Neighboring gene microRNA 7092 Neighboring gene predicted gene, 39520

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Clone Names

    • MGC21593

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity  
    enables GTPase activator activity  
    enables Rab GDP-dissociation inhibitor activity  
    enables Rab GDP-dissociation inhibitor activity  
    enables Rab GDP-dissociation inhibitor activity  
    enables small GTPase binding  
    enables small GTPase binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in axon  
    located_in axon  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum  
    located_in midbody  
    located_in midbody  
    located_in myelin sheath PubMed 
    located_in myelin sheath  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in presynaptic cytosol  
    is_active_in presynaptic cytosol  
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    rab GDP dissociation inhibitor alpha
    Names
    GDI-1
    Rab GDIalpha
    guanosine diphosphate (GDP) dissociation inhibitor 1
    guanosine diphosphate dissociation inhibitor 1
    rab GDI alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010273.4NP_034403.1  rab GDP dissociation inhibitor alpha

      See identical proteins and their annotated locations for NP_034403.1

      Status: VALIDATED

      Source sequence(s)
      AK028880, BB613634, BC013758, CJ293471
      Consensus CDS
      CCDS30227.1
      UniProtKB/Swiss-Prot
      A2AMA8, P50396, Q3TBI9, Q8VHM3, Q91Y71, Q91Z41, Q96CX5
      Related
      ENSMUSP00000015435.5, ENSMUST00000015435.11
      Conserved Domains (1) summary
      pfam00996
      Location:1436
      GDI; GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      73348618..73355473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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