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    Akr1b1 aldo-keto reductase family 1 member B [ Mus musculus (house mouse) ]

    Gene ID: 11677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akr1b1provided by MGI
    Official Full Name
    aldo-keto reductase family 1 member Bprovided by MGI
    Primary source
    MGI:MGI:1353494
    See related
    Ensembl:ENSMUSG00000001642 AllianceGenome:MGI:1353494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AR; ALR2; Ahr1; Ahr-1; Aldr1; Akr1b3; Aldor1
    Summary
    Enables L-glucuronate reductase activity and aldose reductase (NADPH) activity. Involved in L-ascorbic acid biosynthetic process and fructose biosynthetic process. Acts upstream of or within several processes, including metanephric collecting duct development; regulation of urine volume; and renal water homeostasis. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 290.1), heart adult (RPKM 93.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Akr1b1 in Genome Data Viewer
    Location:
    6 14.87 cM; 6 B1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34280865..34294424, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34303930..34317489, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34126896-34127097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34132037-34132238 Neighboring gene STARR-seq mESC enhancer starr_15530 Neighboring gene predicted gene 13855 Neighboring gene predicted gene, 32533 Neighboring gene STARR-seq mESC enhancer starr_15531 Neighboring gene STARR-seq mESC enhancer starr_15532 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34267489-34267672 Neighboring gene STARR-seq mESC enhancer starr_15533 Neighboring gene STARR-seq mESC enhancer starr_15534 Neighboring gene aldo-keto reductase family 1, member B8 Neighboring gene cancer susceptibility candidate 4 pseudogene Neighboring gene RIO kinase 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Aldose reductase deficiency improves Wallerian degeneration and nerve regeneration in diabetic thy1-YFP mice. Chen YS, et al. J Neuropathol Exp Neurol, 2010 Mar. PMID 20142761
    2. Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis. Qiu L, et al. PLoS One, 2013. PMID 24066058, Free PMC Article
    3. Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-κB and MAPK pathways. Zeng KW, et al. Toxicol Appl Pharmacol, 2013 Nov 15. PMID 24021941
    4. Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates. Baba SP, et al. J Biol Chem, 2013 Sep 27. PMID 23928303, Free PMC Article
    5. Diabetes-induced impairment in visual function in mice: contributions of p38 MAPK, rage, leukocytes, and aldose reductase. Lee CA, et al. Invest Ophthalmol Vis Sci, 2014 May 2. PMID 23920367, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis.
      Title: SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis.
    2. High incidence of sebaceous gland inflammation in aldose reductase-deficient mice.
      Title: High incidence of sebaceous gland inflammation in aldose reductase-deficient mice.
    3. Pivotal role of AKR1B1 in pathogenesis of colitis associated colorectal carcinogenesis.
      Title: Pivotal role of AKR1B1 in pathogenesis of colitis associated colorectal carcinogenesis.
    4. Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis.
      Title: Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis.
    5. Aldose reductase promotes diet-induced obesity via induction of senescence in subcutaneous adipose tissue.
      Title: Aldose reductase promotes diet-induced obesity via induction of senescence in subcutaneous adipose tissue.
    6. Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease.
      Title: Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease.
    7. AR deficiency accentuates the pathological effects of transverse aortic constriction.
      Title: Deficiency of aldose reductase exacerbates early pressure overload-induced cardiac dysfunction and autophagy in mice.
    8. modulation of macrophage metabolism by inhibition of AR might represent a novel strategy to modulate host defense responses and to modify metabolism to promote macrophage hypertrophy and phagocytosis under inflammatory conditions
      Title: Aldose reductase (AKR1B) deficiency promotes phagocytosis in bone marrow derived mouse macrophages.
    9. Aldose reductase acts as a switch which can regulate microglia by polarizing cells after spinal cord injury.
      Title: Aldose Reductase Regulates Microglia/Macrophages Polarization Through the cAMP Response Element-Binding Protein After Spinal Cord Injury in Mice.
    10. AR overexpression elevates retinal microglia activation in retina.
      Title: Aldose reductase mediates retinal microglia activation.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-glucuronate reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables allyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glyceraldehyde oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyceraldehyde oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prostaglandin H2 endoperoxidase reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinal dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinal dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hyperosmotic salinity response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular hyperosmotic salinity response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to methylglyoxal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in daunorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in doxorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fructose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner medullary collecting duct development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metanephric collecting duct development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monosaccharide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in norepinephrine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of urine volume IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of urine volume IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within renal water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sorbitol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Schmidt-Lanterman incisure ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Schwann cell microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mast cell granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in paranodal junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane bounded cell projection cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member B1
    Names
    aldehyde reductase 1
    aldo-keto reductase family 1 member B3
    aldose reductase
    NP_033788.3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009658.3 → NP_033788.3  aldo-keto reductase family 1 member B1

      See identical proteins and their annotated locations for NP_033788.3

      Status: VALIDATED

      Source sequence(s)
      AK164682, AV301527, BY749711
      Consensus CDS
      CCDS19990.1
      UniProtKB/Swiss-Prot
      O70130, P45376, Q99KC9
      UniProtKB/TrEMBL
      Q3UDY1, Q5U415
      Related
      ENSMUSP00000100045.5, ENSMUST00000102980.11
      Conserved Domains (2) summary
      COG0656
      Location:1 → 297
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:8 → 289
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      34280865..34294424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45376.3 GenPept UniProtKB/Swiss-Prot:P45376

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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