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    Opn5 opsin 5 [ Mus musculus (house mouse) ]

    Gene ID: 353344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Opn5provided by MGI
    Official Full Name
    opsin 5provided by MGI
    Primary source
    MGI:MGI:2662912
    See related
    Ensembl:ENSMUSG00000043972 AllianceGenome:MGI:2662912
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGR12; Gpr136; TMEM13; Neuropsin
    Summary
    Enables 11-cis retinal binding activity and G protein-coupled photoreceptor activity. Involved in entrainment of circadian clock by photoperiod; hyaloid vascular plexus regression; and phototransduction, UV. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human OPN5 (opsin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Opn5 in Genome Data Viewer
    Location:
    17 19.65 cM; 17 B3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (42867670..42922321, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (42556779..42611430, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42558 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_42559 Neighboring gene STARR-seq mESC enhancer starr_42560 Neighboring gene STARR-seq mESC enhancer starr_42561 Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene STARR-seq mESC enhancer starr_42562 Neighboring gene STARR-seq mESC enhancer starr_42563 Neighboring gene STARR-seq mESC enhancer starr_42564 Neighboring gene STARR-seq mESC enhancer starr_42565 Neighboring gene STARR-seq mESC enhancer starr_42566 Neighboring gene patched domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_42567 Neighboring gene STARR-seq mESC enhancer starr_42568 Neighboring gene STARR-seq mESC enhancer starr_42569 Neighboring gene STARR-seq mESC enhancer starr_42570 Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene 40S ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells. Kamalabadi-Farahani M, et al. BMC Res Notes, 2022 Sep 5. PMID 36064446, Free PMC Article
    2. Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells. D'Souza SP, et al. J Comp Neurol, 2022 Jun. PMID 34743323, Free PMC Article
    3. Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice. Jiang X, et al. Proc Natl Acad Sci U S A, 2021 Jun 1. PMID 34031241, Free PMC Article
    4. Neuropsin Expression Correlates with Dendritic Marker MAP2c Level in Different Brain Regions of Aging Mice. Konar A, et al. Mol Neurobiol, 2015. PMID 24965600
    5. Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina. Jeong H, et al. Sci Rep, 2023 Oct 19. PMID 37857760, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM.
      Title: Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM.
    2. Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina.
      Title: Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina.
    3. Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells.
      Title: Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells.
    4. Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.
      Title: Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.
    5. Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
      Title: Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
    6. Neuropsin in mental health.
      Title: Neuropsin in mental health.
    7. Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
      Title: Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
    8. Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.
      Title: Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.
    9. The study identify violet light as a developmental timing cue that, via an OPN5-dopamine pathway, regulates optic axis clearance in preparation for visual function.
      Title: An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye.
    10. These results suggest that the neuropsin-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin-expressing interneurons, and that neuropsin regulates E/I balance and gamma oscillations through NRG1-ErbB4 signaling toward parvalbumin-expressing interneurons.
      Title: Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 11-cis retinal binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 11-cis retinal binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 11-cis retinal binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled photoreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled photoreceptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV-A IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV-A ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of visible light IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hyaloid vascular plexus regression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction, UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction, UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in photoreceptor outer segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    opsin-5
    Names
    G protein-coupled receptor 136
    G-protein coupled receptor PGR12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181753.4 → NP_861418.2  opsin-5

      See identical proteins and their annotated locations for NP_861418.2

      Status: PROVISIONAL

      Source sequence(s)
      AC110552
      Consensus CDS
      CCDS37619.1
      UniProtKB/Swiss-Prot
      Q059L5, Q6VZZ7, Q7TQP1, Q80T51, Q8BYI2
      Related
      ENSMUSP00000063542.7, ENSMUST00000068355.8
      Conserved Domains (1) summary
      pfam00001
      Location:50 → 306
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      42867670..42922321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524453.1 → XP_006524516.1  opsin-5 isoform X1

      Conserved Domains (1) summary
      cd15074
      Location:7 → 278
      7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_017317518.1 → XP_017173007.1  opsin-5 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:35 → 61
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:34 → 140
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6VZZ7.1 GenPept UniProtKB/Swiss-Prot:Q6VZZ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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