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    Hes6 hairy and enhancer of split 6 [ Mus musculus (house mouse) ]

    Gene ID: 55927, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hes6provided by MGI
    Official Full Name
    hairy and enhancer of split 6provided by MGI
    Primary source
    MGI:MGI:1859852
    See related
    Ensembl:ENSMUSG00000067071 AllianceGenome:MGI:1859852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bHLHb41
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Acts upstream of or within cell differentiation; nervous system development; and regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 71.2), CNS E11.5 (RPKM 41.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hes6 in Genome Data Viewer
    Location:
    1 D; 1 46.12 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91339204..91342901, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91411483..91414038, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene erythroferrone Neighboring gene integrin-linked kinase-associated serine/threonine phosphatase 2C Neighboring gene RIKEN cDNA 1700020N18 gene Neighboring gene STARR-positive B cell enhancer ABC_E5783 Neighboring gene period circadian clock 2 Neighboring gene predicted gene, 35591 Neighboring gene STARR-positive B cell enhancer ABC_E986 Neighboring gene predicted gene 28382

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus  
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    transcription cofactor HES-6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360899.1NP_001347828.1  transcription cofactor HES-6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC110510
      Conserved Domains (2) summary
      cd00083
      Location:2373
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam07527
      Location:94132
      Hairy_orange; Hairy Orange
    2. NM_001360900.1NP_001347829.1  transcription cofactor HES-6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC110510, BY082192
      Conserved Domains (1) summary
      pfam07527
      Location:131
      Hairy_orange; Hairy Orange
    3. NM_019479.3NP_062352.1  transcription cofactor HES-6 isoform 1

      See identical proteins and their annotated locations for NP_062352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK076135
      Consensus CDS
      CCDS15163.1
      UniProtKB/Swiss-Prot
      Q3U2D7, Q9JHE6
      Related
      ENSMUSP00000084062.2, ENSMUST00000086851.2
      Conserved Domains (2) summary
      pfam07527
      Location:96134
      Hairy_orange; Hairy Orange
      cl00081
      Location:2481
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      91339204..91342901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152469.1XP_036008362.1  transcription cofactor HES-6 isoform X1

      UniProtKB/Swiss-Prot
      Q3U2D7, Q9JHE6
      Conserved Domains (2) summary
      pfam07527
      Location:96134
      Hairy_orange; Hairy Orange
      cl00081
      Location:2481
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
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