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    Pcyox1l prenylcysteine oxidase 1 like [ Mus musculus (house mouse) ]

    Gene ID: 240334, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pcyox1lprovided by MGI
    Official Full Name
    prenylcysteine oxidase 1 likeprovided by MGI
    Primary source
    MGI:MGI:3606062
    See related
    Ensembl:ENSMUSG00000024579 AllianceGenome:MGI:3606062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C630049M13
    Summary
    Predicted to enable prenylcysteine oxidase activity. Involved in neutrophil-mediated killing of bacterium. Predicted to be located in extracellular region. Orthologous to human PCYOX1L (prenylcysteine oxidase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 10.6), CNS E11.5 (RPKM 8.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcyox1l in Genome Data Viewer
    Location:
    18 E1; 18 34.68 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61829907..61840712, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61696164..61708114, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 143 Neighboring gene interleukin 17B Neighboring gene predicted gene, 38165 Neighboring gene STARR-positive B cell enhancer mm9_chr18:61857809-61858110 Neighboring gene STARR-seq mESC enhancer starr_44762 Neighboring gene GrpE-like 2, mitochondrial Neighboring gene predicted gene, 17883 Neighboring gene STARR-positive B cell enhancer ABC_E8720 Neighboring gene RIKEN cDNA 1500015A07 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities. Petenkova A, et al. Nat Commun, 2023 May 13. PMID 37179332, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities.
      Title: Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables prenylcysteine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prenylcysteine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neutrophil-mediated killing of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in prenylated protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prenylcysteine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prenylcysteine oxidase-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418426.1 → NP_001405355.1  prenylcysteine oxidase-like isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC125157

    2. NM_001418431.1 → NP_001405360.1  prenylcysteine oxidase-like isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC125157

    3. NM_001418432.1 → NP_001405361.1  prenylcysteine oxidase-like isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC125157

    4. NM_001418435.1 → NP_001405364.1  prenylcysteine oxidase-like isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC125157

    5. NM_001418439.1 → NP_001405368.1  prenylcysteine oxidase-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC125157

    6. NM_001418441.1 → NP_001405370.1  prenylcysteine oxidase-like isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC125157

    7. NM_001418444.1 → NP_001405373.1  prenylcysteine oxidase-like isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC125157

    8. NM_001418446.1 → NP_001405375.1  prenylcysteine oxidase-like isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC125157

    9. NM_172832.5 → NP_766420.1  prenylcysteine oxidase-like isoform 1 precursor

      See identical proteins and their annotated locations for NP_766420.1

      Status: VALIDATED

      Source sequence(s)
      AC125157
      Consensus CDS
      CCDS29287.1
      UniProtKB/Swiss-Prot
      Q8C7K6
      Related
      ENSMUSP00000025472.2, ENSMUST00000025472.7
      Conserved Domains (2) summary
      pfam07156
      Location:122 → 484
      Prenylcys_lyase; Prenylcysteine lyase
      pfam13450
      Location:31 → 96
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61829907..61840712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C7K6.1 GenPept UniProtKB/Swiss-Prot:Q8C7K6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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