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    Tmem132a transmembrane protein 132A [ Mus musculus (house mouse) ]

    Gene ID: 98170, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem132aprovided by MGI
    Official Full Name
    transmembrane protein 132Aprovided by MGI
    Primary source
    MGI:MGI:2147810
    See related
    Ensembl:ENSMUSG00000024736 AllianceGenome:MGI:2147810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orai1; Hspa5bp1; 6720481D13Rik
    Summary
    Enables protein homodimerization activity. Acts upstream of or within negative regulation of protein catabolic process; positive regulation of Wnt protein secretion; and positive regulation of Wnt signaling pathway. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb bud; lung; and spinal ganglion. Orthologous to human TMEM132A (transmembrane protein 132A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 93.6), whole brain E14.5 (RPKM 86.6) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem132a in Genome Data Viewer
    Location:
    19 A; 19 7.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10835193..10847569, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10857829..10870205, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430093F15 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10861955-10862189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10862842-10863029 Neighboring gene CD6 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10903953-10904062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10904315-10904608 Neighboring gene STARR-seq mESC enhancer starr_45559 Neighboring gene STARR-positive B cell enhancer ABC_E5688 Neighboring gene solute carrier family 15, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E2520 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10956481-10956590 Neighboring gene transmembrane protein 109 Neighboring gene STARR-positive B cell enhancer ABC_E8738 Neighboring gene pre-mRNA processing factor 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional and post-transcriptional regulation of transmembrane protein 132A. Oh-Hashi K, et al. Mol Cell Biochem, 2015 Jul. PMID 25926156
    2. Characterization of the expression and cell-surface localization of transmembrane protein 132A. Oh-hashi K, et al. Mol Cell Biochem, 2012 Nov. PMID 22821197
    3. TMEM132A regulates Wnt/β-catenin signaling through stabilizing LRP6 during mouse embryonic development. Oh SA, et al. Cell Commun Signal, 2024 Oct 9. PMID 39385148, Free PMC Article
    4. TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction. Li B, et al. Front Cell Dev Biol, 2020. PMID 33324648, Free PMC Article
    5. Essential role of the N-terminus of murine Orai1 in store-operated Ca2+ entry. Takahashi Y, et al. Biochem Biophys Res Commun, 2007 Apr 27. PMID 17343823

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM132A regulates mouse hindgut morphogenesis and caudal development.
      Title: TMEM132A regulates mouse hindgut morphogenesis and caudal development.
    2. TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.
      Title: TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.
    3. Markedly attenuated the levels of TMEM132A mRNA.
      Title: Transcriptional and post-transcriptional regulation of transmembrane protein 132A.
    4. The novel cell-surface localized glycoprotein, TMEM132A, is regulated by several factors, including GRP78, Sar1, and intracellular calcium, in a post-transcriptional manner.
      Title: Characterization of the expression and cell-surface localization of transmembrane protein 132A.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of Wnt protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 132A
    Names
    HSPA5-binding protein 1
    heat shock 70kDa protein 5 binding protein 1
    heat shock protein 5 binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378918.1 → NP_001365847.1  transmembrane protein 132A isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC132402
      Conserved Domains (3) summary
      pfam15705
      Location:44 → 167
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:831 → 896
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:404 → 746
      TMEM132; Transmembrane protein family 132

    2. NM_133804.2 → NP_598565.2  transmembrane protein 132A isoform 1 precursor

      See identical proteins and their annotated locations for NP_598565.2

      Status: VALIDATED

      Source sequence(s)
      AK048556, AK173207, CF729397
      Consensus CDS
      CCDS29589.1
      UniProtKB/Swiss-Prot
      Q69ZF9, Q8BX93, Q922P8
      Related
      ENSMUSP00000025645.8, ENSMUST00000025645.14
      Conserved Domains (3) summary
      pfam15705
      Location:44 → 167
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:830 → 897
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:403 → 744
      TMEM132; Transmembrane protein family 132

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10835193..10847569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003952832.1 RNA Sequence

      Related
      ENSMUST00000120524.2

    2. XR_386529.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922P8.2 GenPept UniProtKB/Swiss-Prot:Q922P8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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