U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cyld CYLD lysine 63 deubiquitinase [ Mus musculus (house mouse) ]

    Gene ID: 74256, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyldprovided by MGI
    Official Full Name
    CYLD lysine 63 deubiquitinaseprovided by MGI
    Primary source
    MGI:MGI:1921506
    See related
    Ensembl:ENSMUSG00000036712 AllianceGenome:MGI:1921506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EAC; CDMT; CYLD1; mKIAA0849; 2010013M14Rik; 2900009M21Rik; C130039D01Rik
    Summary
    This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 5.8), cortex adult (RPKM 5.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cyld in Genome Data Viewer
    Location:
    8 C3; 8 43.51 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (89423506..89478574)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88696878..88751946)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22236 Neighboring gene STARR-seq mESC enhancer starr_22237 Neighboring gene STARR-positive B cell enhancer ABC_E2869 Neighboring gene sorting nexin 20 Neighboring gene STARR-positive B cell enhancer ABC_E3791 Neighboring gene STARR-positive B cell enhancer ABC_E6672 Neighboring gene nucleotide-binding oligomerization domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E108 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene nucleophosmin 1 pseudogene Neighboring gene ribosomal protein S6, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_22238 Neighboring gene predicted gene, 42034

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (12)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Met1-linked polyubiquitin deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables proline-rich region binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in necroptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-18-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of p38MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein linear deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein linear deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of necroptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ripoptosome assembly involved in necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with midbody ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase CYLD
    Names
    cylindromatosis (turban tumor syndrome)
    deubiquitinating enzyme CYLD
    ubiquitin thioesterase CYLD
    ubiquitin thiolesterase CYLD
    ubiquitin-specific-processing protease CYLD
    NP_001121642.1
    NP_001121643.1
    NP_001263208.1
    NP_775545.1
    XP_006531477.1
    XP_006531478.1
    XP_006531479.1
    XP_006531480.1
    XP_006531481.1
    XP_006531482.1
    XP_006531483.1
    XP_011246825.1
    XP_011246826.1
    XP_011246827.1
    XP_030099667.1
    XP_030099668.1
    XP_030099669.1
    XP_030099671.1
    XP_030099672.1
    XP_036010220.1
    XP_036010221.1
    XP_036010222.1
    XP_036010223.1
    XP_036010225.1
    XP_036010226.1
    XP_036010227.1
    XP_036010228.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128170.2NP_001121642.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform a

      See identical proteins and their annotated locations for NP_001121642.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame exon in the coding region compared to variant 2. It encodes isoform a which is longer than isoform b.
      Source sequence(s)
      AC138025, AC156937, AK147204
      Consensus CDS
      CCDS52633.1
      UniProtKB/TrEMBL
      Q3V028
      Related
      ENSMUSP00000147654.2, ENSMUST00000209532.2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    2. NM_001128171.2NP_001121643.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform b

      See identical proteins and their annotated locations for NP_001121643.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode isoform b.
      Source sequence(s)
      AC138025, AC156937
      Consensus CDS
      CCDS22513.1
      UniProtKB/Swiss-Prot
      Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
      UniProtKB/TrEMBL
      Q3V028
      Related
      ENSMUSP00000148037.2, ENSMUST00000211554.2
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    3. NM_001276279.1NP_001263208.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform c

      See identical proteins and their annotated locations for NP_001263208.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as short (s)-CYLD) differs in the 5' UTR and lacks several alternate exons in the coding region compared to variant 2. It encodes isoform c which is shorter than isoform b.
      Source sequence(s)
      AC138025, AC156937
      Consensus CDS
      CCDS85579.1
      UniProtKB/TrEMBL
      A0A1B0GSE5, Q3TJI3
      Related
      ENSMUSP00000147904.2, ENSMUST00000209206.2
      Conserved Domains (3) summary
      smart01052
      Location:127203
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:407762
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304375
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    4. NM_173369.3NP_775545.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform b

      See identical proteins and their annotated locations for NP_775545.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b. Both variants 2 and 4 encode isoform b.
      Source sequence(s)
      AC138025, AC156937
      Consensus CDS
      CCDS22513.1
      UniProtKB/Swiss-Prot
      Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
      UniProtKB/TrEMBL
      Q3V028
      Related
      ENSMUSP00000147426.2, ENSMUST00000209559.2
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      89423506..89478574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243811.1XP_030099671.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

      UniProtKB/Swiss-Prot
      Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    2. XM_006531419.2XP_006531482.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

      UniProtKB/TrEMBL
      Q3TJI3
      Conserved Domains (3) summary
      smart01052
      Location:127203
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:410765
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307379
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    3. XM_006531420.3XP_006531483.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

      See identical proteins and their annotated locations for XP_006531483.1

      UniProtKB/TrEMBL
      A0A1B0GSE5, Q3TJI3
      Conserved Domains (3) summary
      smart01052
      Location:127203
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:407762
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304375
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    4. XM_036154328.1XP_036010221.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

      UniProtKB/TrEMBL
      A0A1B0GSE5, Q3TJI3
      Conserved Domains (3) summary
      smart01052
      Location:127203
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:407762
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304375
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    5. XM_006531416.5XP_006531479.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531479.1

      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    6. XM_036154330.1XP_036010223.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X5

      Conserved Domains (3) summary
      smart01052
      Location:249317
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:370725
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:85248
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    7. XM_036154335.1XP_036010228.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X7

      Conserved Domains (2) summary
      smart01052
      Location:1064
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:185540
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    8. XM_030243809.1XP_030099669.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

      UniProtKB/Swiss-Prot
      Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    9. XM_036154333.1XP_036010226.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X6

      Conserved Domains (3) summary
      smart01052
      Location:246314
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:367722
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:82245
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    10. XM_030243807.1XP_030099667.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

      UniProtKB/Swiss-Prot
      Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    11. XM_006531417.4XP_006531480.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531480.1

      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    12. XM_036154329.1XP_036010222.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

      UniProtKB/TrEMBL
      A0A1B0GSE5, Q3TJI3
      Conserved Domains (3) summary
      smart01052
      Location:127203
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:407762
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304375
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    13. XM_011248525.4XP_011246827.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_011246827.1

      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    14. XM_006531414.3XP_006531477.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531477.1

      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    15. XM_030243812.2XP_030099672.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

      UniProtKB/Swiss-Prot
      Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    16. XM_030243808.1XP_030099668.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

      UniProtKB/Swiss-Prot
      Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    17. XM_006531415.2XP_006531478.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531478.1

      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    18. XM_011248524.3XP_011246826.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_011246826.1

      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    19. XM_036154332.1XP_036010225.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X5

      Conserved Domains (3) summary
      smart01052
      Location:249317
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:370725
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:85248
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    20. XM_036154334.1XP_036010227.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X6

      Conserved Domains (3) summary
      smart01052
      Location:246314
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:367722
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:82245
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    21. XM_011248523.4XP_011246825.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_011246825.1

      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    22. XM_006531418.4XP_006531481.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531481.1

      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    23. XM_036154327.1XP_036010220.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

      UniProtKB/Swiss-Prot
      Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
      UniProtKB/TrEMBL
      Q3V028
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001128169.1: Suppressed sequence

      Description
      NM_001128169.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.