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    Dio2 deiodinase, iodothyronine, type II [ Mus musculus (house mouse) ]

    Gene ID: 13371, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dio2provided by MGI
    Official Full Name
    deiodinase, iodothyronine, type IIprovided by MGI
    Primary source
    MGI:MGI:1338833
    See related
    Ensembl:ENSMUSG00000007682 AllianceGenome:MGI:1338833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5DII; DIOII
    Summary
    The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is highly expressed in brain, placenta and mammary gland. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. Knockout studies in mice suggest that this gene may play an important role in brown adipose tissue lipogenesis, auditory function, and bone formation. This protein is a selenoprotein containing the non-standard amino acid, selenocysteine (Sec), which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Unlike the other two members (DIO1 and DIO3) of this enzyme family, the mRNA for this gene contains an additional in-frame UGA codon that has been reported (in human) to function either as a Sec or a stop codon, resulting in two potential isoforms with one or two Sec residues; however, only the upstream Sec (conserved with the single Sec residue found at the active site in DIO1 and DIO3) was shown to be essential for enzyme activity (PMID:10403186). In addition, the lack of conservation of the protein extension past the second TGA codon suggests that the one-Sec containing isoform represents the canonical form. [provided by RefSeq, Oct 2018]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 14.7), frontal lobe adult (RPKM 8.9) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Dio2 in Genome Data Viewer
    Location:
    12 D3; 12 44.05 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (90691326..90705812, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (90724552..90739038, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40538 Neighboring gene STARR-seq mESC enhancer starr_32922 Neighboring gene LSM14 homolog A pseudogene Neighboring gene STARR-seq mESC enhancer starr_32923 Neighboring gene predicted gene, 26512 Neighboring gene STARR-seq mESC enhancer starr_32924 Neighboring gene nuclear encoded rRNA 5S 65 Neighboring gene predicted gene, 23195

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables thyroxine 5'-deiodinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thyroxine 5'-deiodinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thyroxine 5'-deiodinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thyroxine 5'-deiodinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyroxine 5-deiodinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    type II iodothyronine deiodinase
    Names
    iodothyronine type II deiodinase
    type 2 DI
    type-II 5' deiodinase
    NP_034180.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010050.4NP_034180.2  type II iodothyronine deiodinase

      Status: REVIEWED

      Source sequence(s)
      AK032038, AK045607, BQ033571, CT573100
      Consensus CDS
      CCDS36514.1
      UniProtKB/TrEMBL
      A0A8Z1S5Q0
      Related
      ENSMUSP00000081013.6, ENSMUST00000082432.7
      Conserved Domains (1) summary
      cl00388
      Location:4259
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      90691326..90705812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)