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    Rgs9 regulator of G-protein signaling 9 [ Mus musculus (house mouse) ]

    Gene ID: 19739, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rgs9provided by MGI
    Official Full Name
    regulator of G-protein signaling 9provided by MGI
    Primary source
    MGI:MGI:1338824
    See related
    Ensembl:ENSMUSG00000020599 AllianceGenome:MGI:1338824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RGS9-1; Rgs9-2
    Summary
    Predicted to enable GTPase activator activity. Acts upstream of or within dark adaptation and light adaption. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in bradyopsia 1. Orthologous to human RGS9 (regulator of G protein signaling 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 4.9), genital fat pad adult (RPKM 4.6) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rgs9 in Genome Data Viewer
    Location:
    11 E1; 11 71.86 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109116174..109189013, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109225348..109298181, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 39440 Neighboring gene STARR-seq mESC enhancer starr_31015 Neighboring gene predicted gene, 39441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109173531-109173684 Neighboring gene STARR-positive B cell enhancer ABC_E2374 Neighboring gene STARR-seq mESC enhancer starr_31016 Neighboring gene RIKEN cDNA 1600015H23 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC150267, MGC150268

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within dark adaptation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within light adaption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of G-protein signaling 9
    Names
    ROS GAP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165934.1NP_001159406.1  regulator of G-protein signaling 9 isoform 2

      See identical proteins and their annotated locations for NP_001159406.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK138159, AL604043, BG298879, BY277335
      Consensus CDS
      CCDS48969.1
      UniProtKB/TrEMBL
      Q3UUR0
      Related
      ENSMUSP00000102317.2, ENSMUST00000106706.8
      Conserved Domains (3) summary
      smart00224
      Location:219280
      GGL; G protein gamma subunit-like motifs
      cd08739
      Location:292412
      RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein
      cd04450
      Location:22109
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    2. NM_011268.2NP_035398.2  regulator of G-protein signaling 9 isoform 1

      See identical proteins and their annotated locations for NP_035398.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL604043
      Consensus CDS
      CCDS25576.1
      UniProtKB/Swiss-Prot
      A1L352, O54828, Q9Z0S0
      Related
      ENSMUSP00000020920.4, ENSMUST00000020920.10
      Conserved Domains (3) summary
      smart00224
      Location:219280
      GGL; G protein gamma subunit-like motifs
      cd08739
      Location:292412
      RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein
      cd04450
      Location:22109
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      109116174..109189013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248828.3XP_011247130.2  regulator of G-protein signaling 9 isoform X1