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    Zfy1 zinc finger protein 1, Y-linked [ Mus musculus (house mouse) ]

    Gene ID: 22767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfy1provided by MGI
    Official Full Name
    zinc finger protein 1, Y-linkedprovided by MGI
    Primary source
    MGI:MGI:99212
    See related
    Ensembl:ENSMUSG00000053211 AllianceGenome:MGI:99212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfy2; Zfy-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and lung. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfy1 in Genome Data Viewer
    Location:
    Y; Ypter
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (725207..797409, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (725207..797409, complement)

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene predicted gene 29089 Neighboring gene STARR-seq mESC enhancer starr_48292 Neighboring gene STARR-seq mESC enhancer starr_48293 Neighboring gene ubiquitin-activating enzyme E1, Chr Y 1 pseudogene Neighboring gene ubiquitin-activating enzyme, Chr Y Neighboring gene ras homolog A translocated to the Y, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfyl encodes a nuclear sequence-specific DNA binding protein. Taylor-Harris P, et al. FEBS Lett, 1995 Mar 6. PMID 7883055
    2. RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis. Zhang Y, et al. Mamm Genome, 2017 Apr. PMID 28251288
    3. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Su H, et al. Mol Reprod Dev, 1992 Nov. PMID 1449792
    4. The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers. Mardon G, et al. Cell, 1989 Mar 10. PMID 2493989
    5. Sequence of cDNA for murine Zfy-1, a candidate for Tdy. Ashworth A, et al. Nucleic Acids Res, 1989 Apr 11. PMID 2497440, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
      Title: Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
    2. our findings show that RNAi-mediated disruption of Zfx/Zfy in mouse testis affected X/Y spermatogenesis. Additionally, results suggest that the paralogous genes Zfx/Zfy play an important role in the process of X and Y sperm development. The individual interference of Zfx/Zfy may predict the outcome of X and Y haploid sperms. Presented herein is an advanced method developed to control mouse X/Y spermatogenesis and sex rati
      Title: RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.
    3. we show that in mice, Zfy genes(Zfy1 and Zfy2 ) are also necessary for efficient meiotic sex chrand the sex chromosomes are not correctly silenced in Zfy-deficient spermatocytes.
      Title: Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes.
    4. Zfy1-KO mice did not show any significant phenotypic alterations. Zfy1/2-DKO mice were infertile and displayed abnormal sperm morphology and fertilization failure.
      Title: Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.
    5. genetic information on the short arm of the Y chromosome promotes meiosis II, and by transgene addition Zfy1 and Zfy2 were identified as the genes responsible.
      Title: Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division.
    6. Studies identified a Zfy2 transcript that predominates in spermatids, and a Zfy1 transcript, lacking an exon encoding approximately half of the acidic domain.
      Title: Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger Y-chromosomal protein 1
    Names
    Y-linked zinc finger protein 1
    Y-linked zinc finger protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009570.4 → NP_033596.3  zinc finger Y-chromosomal protein 1

      See identical proteins and their annotated locations for NP_033596.3

      Status: VALIDATED

      Source sequence(s)
      AK076618, X14382
      Consensus CDS
      CCDS30539.1
      UniProtKB/Swiss-Prot
      E9QKM5, P10925, Q8C638
      Related
      ENSMUSP00000069364.5, ENSMUST00000065545.6
      Conserved Domains (6) summary
      COG5048
      Location:513 → 687
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:528 → 548
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:526 → 548
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:68 → 388
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:540 → 562
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      725207..797409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10925.3 GenPept UniProtKB/Swiss-Prot:P10925

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