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    Tldc2 TBC/LysM associated domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 383766, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tldc2provided by MGI
    Official Full Name
    TBC/LysM associated domain containing 2provided by MGI
    Primary source
    MGI:MGI:2686178
    See related
    Ensembl:ENSMUSG00000074628 AllianceGenome:MGI:2686178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1332
    Summary
    Acts upstream of or within negative regulation of cellular response to oxidative stress. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Orthologous to human TLDC2 (TBC/LysM-associated domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 1.6), large intestine adult (RPKM 0.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tldc2 in Genome Data Viewer
    Location:
    2 H1; 2 77.99 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156918542..156938868)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157076627..157096948)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene DSN1 homolog, MIS12 kinetochore complex component Neighboring gene microtubule crosslinking factor 2 Neighboring gene STARR-seq mESC enhancer starr_06195 Neighboring gene STARR-seq mESC enhancer starr_06196 Neighboring gene SAM domain and HD domain, 1 Neighboring gene STARR-seq mESC enhancer starr_06197 Neighboring gene STARR-positive B cell enhancer ABC_E6008 Neighboring gene STARR-positive B cell enhancer ABC_E7876 Neighboring gene STARR-positive B cell enhancer ABC_E2649 Neighboring gene STARR-seq mESC enhancer starr_06198 Neighboring gene RB transcriptional corepressor like 1 Neighboring gene Small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) (Sm-D1) (Sm-D autoantigen)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress. Finelli MJ, et al. J Biol Chem, 2016 Feb 5. PMID 26668325, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TLD domain-containing protein 2
    Names
    TBC/LysM-associated domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177439.2 → NP_001170910.1  TLD domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AL669828
      Consensus CDS
      CCDS50782.1
      UniProtKB/Swiss-Prot
      A2ACG1
      UniProtKB/TrEMBL
      E9PZS3
      Related
      ENSMUSP00000129278.2, ENSMUST00000166140.8
      Conserved Domains (1) summary
      smart00584
      Location:50 → 212
      TLDc; domain in TBC and LysM domain containing proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      156918542..156938868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499838.5 → XP_006499901.1  TLD domain-containing protein 2 isoform X2

      Conserved Domains (1) summary
      smart00584
      Location:115 → 261
      TLDc; domain in TBC and LysM domain containing proteins

    2. XM_006499836.4 → XP_006499899.1  TLD domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499899.1

      Conserved Domains (1) summary
      smart00584
      Location:115 → 261
      TLDc; domain in TBC and LysM domain containing proteins

    3. XM_006499837.4 → XP_006499900.1  TLD domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499900.1

      Conserved Domains (1) summary
      smart00584
      Location:115 → 261
      TLDc; domain in TBC and LysM domain containing proteins

    4. XM_006499841.4 → XP_006499904.1  TLD domain-containing protein 2 isoform X6

      UniProtKB/Swiss-Prot
      A2ACG1
      Conserved Domains (1) summary
      smart00584
      Location:72 → 218
      TLDc; domain in TBC and LysM domain containing proteins

    5. XM_036162348.1 → XP_036018241.1  TLD domain-containing protein 2 isoform X7

      UniProtKB/Swiss-Prot
      A2ACG1
      UniProtKB/TrEMBL
      E9PZS3
      Conserved Domains (1) summary
      smart00584
      Location:50 → 212
      TLDc; domain in TBC and LysM domain containing proteins

    6. XM_006499840.4 → XP_006499903.1  TLD domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      smart00584
      Location:115 → 216
      TLDc; domain in TBC and LysM domain containing proteins

    7. XM_011239652.3 → XP_011237954.1  TLD domain-containing protein 2 isoform X8

      Conserved Domains (1) summary
      cl02144
      Location:115 → 190
      TLD

    8. XM_030251822.2 → XP_030107682.1  TLD domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      smart00584
      Location:115 → 261
      TLDc; domain in TBC and LysM domain containing proteins

    9. XM_036162347.1 → XP_036018240.1  TLD domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      smart00584
      Location:93 → 210
      TLDc; domain in TBC and LysM domain containing proteins

    10. XM_006499839.4 → XP_006499902.1  TLD domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      smart00584
      Location:93 → 255
      TLDc; domain in TBC and LysM domain containing proteins

    11. XM_006499843.5 → XP_006499906.1  TLD domain-containing protein 2 isoform X9

      UniProtKB/Swiss-Prot
      A2ACG1
      Conserved Domains (1) summary
      smart00584
      Location:58 → 204
      TLDc; domain in TBC and LysM domain containing proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2ACG1.1 GenPept UniProtKB/Swiss-Prot:A2ACG1

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