Ly6g lymphocyte antigen 6 family member G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ly6gprovided by MGI
Official Full Name: lymphocyte antigen 6 family member Gprovided by MGI
Primary source: MGI:MGI:109440
See related: Ensembl:ENSMUSG00000022582 AllianceGenome:MGI:109440
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gr1; Gr-1; Ly-6G
Summary: Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Located in external side of plasma membrane. Is expressed in large intestine; small intestine; and spleen. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 27.4) and liver E18 (RPKM 5.3) See more
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Genomic context

Location:: 15 D3; 15 34.29 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (75027110..75030977)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (75155261..75159128)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD11b[+]Gr-1[low] cells that accumulate in M.leprae-induced granulomas of the footpad skin of nude mice have the characteristics of monocytic-myeloid-derived suppressor cells.
Title: CD11b(+)Gr-1(low) cells that accumulate in M.leprae-induced granulomas of the footpad skin of nude mice have the characteristics of monocytic-myeloid-derived suppressor cells.
Depletion of Ly6G-Expressing Neutrophilic Cells Leads to Altered Peripheral T-Cell Homeostasis and Thymic Development in Neonatal Mice.
Title: Depletion of Ly6G-Expressing Neutrophilic Cells Leads to Altered Peripheral T-Cell Homeostasis and Thymic Development in Neonatal Mice.
Ovarian cancer modulates the immunosuppressive function of CD11b(+)Gr1(+) myeloid cells via glutamine metabolism.
Title: Ovarian cancer modulates the immunosuppressive function of CD11b(+)Gr1(+) myeloid cells via glutamine metabolism.
More than neutrophils: Lin(+)Ly6G(+)IL-5Ralpha(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes.
Title: More than neutrophils: Lin(+)Ly6G(+)IL-5Rα(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes.
Trained Innate Immunity Induced by Vaccination with Low-Virulence Candida Species Mediates Protection against Several Forms of Fungal Sepsis via Ly6G(+) Gr-1(+) Leukocytes.
Title: Trained Innate Immunity Induced by Vaccination with Low-Virulence Candida Species Mediates Protection against Several Forms of Fungal Sepsis via Ly6G(+) Gr-1(+) Leukocytes.
Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection.
Title: Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection.
Frontline Science: Cytokine-mediated developmental phenotype of mouse eosinophils: IL-5-associated expression of the Ly6G/Gr1 surface Ag.
Title: Frontline Science: Cytokine-mediated developmental phenotype of mouse eosinophils: IL-5-associated expression of the Ly6G/Gr1 surface Ag.
Findings identify selective inhibition of integrin-mediated neutrophil emigration through Ly6G ligation, highlighting the marked site and stimulus specificity of beta2 integrin dependence in neutrophil migration.
Title: Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation.
ur results connect the Cd101 haplotype-dependent protection from T1D to an anti-diabetogenic function of CD101-expressing Tregs and Gr1-positive myeloid cells and confirm the identity of Cd101 as Idd10.
Title: Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.
CD11b+Gr-1+ myeloid-derived suppressor cells suppress T cells in an IFN-gamma- and nitric oxide-dependent manner to reduce atherosclerotic lesion development in LDLr deficient mice.
Title: CD11b+Gr-1+ myeloid-derived suppressor cells reduce atherosclerotic lesion development in LDLr deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lymphocyte antigen 6G

Names: ly-6G.1; lymphocyte antigen 6 complex, locus G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310438.1 → NP_001297367.1 lymphocyte antigen 6G precursor

See identical proteins and their annotated locations for NP_001297367.1

Status: VALIDATED

Description

Transcript Variant: Both variants 1and 2 encode the same protein.

Source sequence(s)

AC116498

Consensus CDS

CCDS79377.1

UniProtKB/Swiss-Prot

A0A087WQF5, P35461

UniProtKB/TrEMBL

A0A668H4Q1

Related

ENSMUSP00000140173.2, ENSMUST00000190262.2

Conserved Domains (1) summary

pfam00021
Location:29 → 105

UPAR_LY6; u-PAR/Ly-6 domain
NM_001374230.1 → NP_001361159.1 lymphocyte antigen 6G precursor

Status: VALIDATED

Description

Transcript Variant: Both variants 1and 2 encode the same protein.

Source sequence(s)

AC116498

Consensus CDS

CCDS79377.1

UniProtKB/Swiss-Prot

A0A087WQF5, P35461

UniProtKB/TrEMBL

A0A668H4Q1

Conserved Domains (1) summary

pfam00021
Location:29 → 105

UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

75027110..75030977

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_008531.1: Suppressed sequence

Description

NM_008531.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.