Nkiras1 NFKB inhibitor interacting Ras-like protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nkiras1provided by MGI
Official Full Name: NFKB inhibitor interacting Ras-like protein 1provided by MGI
Primary source: MGI:MGI:1916971
See related: Ensembl:ENSMUSG00000021772 AllianceGenome:MGI:1916971
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KBRAS1; kappaB-Ras1; 2400004O09Rik
Summary: Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Predicted to be located in cytosol and endoplasmic reticulum. Orthologous to human NKIRAS1 (NFKB inhibitor interacting Ras like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cortex adult (RPKM 13.7), cerebellum adult (RPKM 13.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 7.08 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (4185693..4198560, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (18271136..18284003)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activating protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ral protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Ral protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung alveolus development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within surfactant homeostasis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NF-kappa-B inhibitor-interacting Ras-like protein 1

Names: I-kappa-B-interacting Ras-like protein 1; kappa B-Ras protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316711.1 → NP_001303640.1 NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC154489, AK010285, AK028539, AW490494, BC054390, BY332128

UniProtKB/Swiss-Prot

Q8CEC5

Conserved Domains (1) summary

cl38936
Location:8 → 138

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001316712.1 → NP_001303641.1 NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC154489, AK028539, AW490494, BC054390, BY114837, BY332128

UniProtKB/Swiss-Prot

Q8CEC5

Conserved Domains (1) summary

cl21455
Location:12 → 142

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_023526.4 → NP_076015.2 NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_076015.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC154489, AK028539, AW490494, BC054390, BY332128

Consensus CDS

CCDS26836.1

UniProtKB/Swiss-Prot

Q8CEC5, Q9JKV3

Related

ENSMUSP00000121496.2, ENSMUST00000132374.9

Conserved Domains (1) summary

cl38936
Location:6 → 168

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

4185693..4198560 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247999.1 → XP_030103859.1 NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

Conserved Domains (1) summary

cl38936
Location:8 → 138

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_036158841.1 → XP_036014734.1 NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

Conserved Domains (1) summary

cl38936
Location:8 → 138

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006518097.5 → XP_006518160.1 NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006518160.1

UniProtKB/Swiss-Prot

Q8CEC5, Q9JKV3

Conserved Domains (1) summary

cl38936
Location:6 → 168

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases